Neurobiol Dis 2017 Oct 12;106:205-213. Epub 2017 Jul 12.
Montreal Neurological Institute, Department of Neurology & Neurosurgery, McGill University, 3801 University Street, Montréal, QC H3A 2B4, Canada; Montreal Neurological Institute, Department Physiology, McGill University, 3801 University Street, Montréal, QC H3A 2B4, Canada. Electronic address:
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Epilepsy Res 2015 Sep 19;115:8-16. Epub 2015 May 19.
Montreal Neurological Institute and Department of Neurology & Neurosurgery, McGill University, 3801 University Street, Montréal, QC, Canada H3A 2B4. Electronic address:
Objective: Nearly one third of patients presenting with mesial temporal lobe epilepsy (MTLE), the most prevalent lesion-related epileptic disorder in adulthood, do not respond to currently available antiepileptic medications. Thus, there is a need to identify and characterize new antiepileptic drugs. In this study, we used the pilocarpine model of MTLE to establish the effects of a third generation drug, lacosamide (LCM), on seizures, interictal spikes and high-frequency oscillations (HFOs, ripples: 80-200 Hz, fast ripples: 250-500 Hz). Read More
J Neurosci 2012 Sep;32(38):13264-72
Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada H3A 2B4.
High-frequency oscillations (HFOs; 80-500 Hz) are thought to mirror the pathophysiological changes occurring in epileptic brains. However, the distribution of HFOs during seizures remains undefined. Here, we recorded from the hippocampal CA3 subfield, subiculum, entorhinal cortex, and dentate gyrus to quantify the occurrence of ripples (80-200 Hz) and fast ripples (250-500 Hz) during low-voltage fast-onset (LVF) and hypersynchronous-onset (HYP) seizures in the rat pilocarpine model of temporal lobe epilepsy. Read More
Seizure 2015 Feb 26;25:18-25. Epub 2014 Nov 26.
Montreal Neurological Institute and Department of Neurology & Neurosurgery, McGill University, Montréal, Qc H3A 2B4, Canada. Electronic address:
Purpose: Mesial temporal lobe epilepsy (MTLE) is the most prevalent type of partial epileptic disorders. In this study, we have analyzed the impact of levetiracetam (LEV) in the pilocarpine model of MTLE.
Methods: Sprague-Dawley rats (n=19) were injected with pilocarpine (380 mg/kg, i. Read More
Epilepsia 2016 Jan 26;57(1):111-21. Epub 2015 Nov 26.
Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, U.S.A.
Objective: To characterize local field potentials, high frequency oscillations, and single unit firing patterns in microelectrode recordings of human limbic onset seizures.
Methods: Wide bandwidth local field potential recordings were acquired from microelectrodes implanted in mesial temporal structures during spontaneous seizures from six patients with mesial temporal lobe epilepsy.
Results: In the seizure onset zone, distinct epileptiform discharges were evident in the local field potential prior to the time of seizure onset in the intracranial EEG. Read More