J Dermatol 2017 Oct 10;44(10):e254-e255. Epub 2017 Jul 10.
Department of Dermatology, Fujita Health University School of Medicine, Toyoake, Japan.
|PDF Download - Full Text Link
( Please be advised that this article is hosted on an external website not affiliated with PubFacts.com)
J Dermatol 1994 Oct;21(10):755-9
Department of Dermatology, Mie University, Faculty of Medicine, Tsu, Japan.
To treat severe painful digital ulcers on progressive systemic sclerosis (PSS) patients, we developed a new combination therapy which included neural blockade, intravenous urokinase, and prostaglandin E1 infusion. All of these are already recognized treatments for circulatory disturbances in PSS. Although each of them alone has a limited effect on the painful ischemic attack in PSS; in stepwise combination, neural blockade for release of vascular spasm and pain, prostaglandin E1 for further vasodilatation, and urokinase for thrombolysis were effective in the treatment of digital ischemia in two PSS patients. Read More
Br J Dermatol 2006 Dec;155(6):1159-64
Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan.
Background: Although digital ulcerations frequently occur in patients with systemic sclerosis (SSc), there have been few reports on the macrovascular involvement.
Objectives: To evaluate the macrovascular involvement in patients with SSc exhibiting digital ulceration or gangrene.
Methods: Transfemoral catheter arteriography of the upper and/or lower extremities was performed in eight patients (one man and seven women, age range 42-71 years) with SSc exhibiting digital ulceration or gangrene. Read More
Case Rep Med 2013 3;2013:690591. Epub 2013 Apr 3.
Department of Dermatology, University Hospital, KU Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium.
Digital ulcers are a well-known problem in patients with systemic sclerosis. Lower extremity ulcers are less prevalent but are also a challenging and underestimated complication of the disease causing important pain and morbidity. Bosentan, an oral dual endothelin receptor antagonist, has been shown to be effective in preventing digital ulcers in patients with systemic sclerosis. Read More
Srp Arh Celok Lek 1992 Jan-Feb;120(1-2):9-14
Institute for Cardiovaskular Diseases, University Clinical Centre, Belgrade.
The authors present their result of a two-year follow-up of 106 patients to whom an intra-arterial perfusion of prostaglandin E1 was administered, as limb salvage procedure. The patients were in the IIIrd and IVth stage of occlusive diseases by Fountain, and surgical reconstructions were not possible. All patients were divided into five groups: A--diabetic angiopathy (5), B--distal form of atherosclerosis (40), C--diabetic angiopathy and atherosclerosis (45), D--Burger disease (10) and E--adjuvant therapy in reconstruction with poor run-off (6). Read More