Of self-lipids, CD1-restricted T cells, and contact sensitization.

Eur J Immunol 2017 07;47(7):1119-1122

Experimental Immunology Unit, Division of Immunology, Transplantation and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy.

Contact hypersensitivity (CHS) in rodents and contact dermatitis in humans are long-known pathological conditions caused by MHC-restricted T-cell responses. These responses are triggered upon T-cell recognition of neo-antigenic determinants, which are generated by a variety of environmental contact sensitizer (CS) chemicals associating with self-proteins to comprise these neo-antigens. In this issue of the European Journal of Immunology, Betts et al. [Eur. J. Immunol. 2017. 47: 1171-1180] provide intriguing data implying that common small molecule CSs such as dinitrochlorobenzene can also recruit and activate autoreactive CD1-restricted T cells specific for cell-endogenous lipids, which are enriched in human skin. The effects of dinitrochlorobenzene on CD1 T-cell recruitment and function were dependent on newly synthesized CD1 molecules and the presence of endogenous lipids. These findings shed new light on unanticipated mechanisms that have potential clinical relevance on a common and highly distressing disease state.

Download full-text PDF

Source
http://dx.doi.org/10.1002/eji.201747112DOI Listing
July 2017
9 Reads

Publication Analysis

Top Keywords

cd1-restricted cells
8
betts et al
4
synthesized cd1
4
immunology betts
4
et al [eur
4
cd1 molecules
4
journal immunology
4
newly synthesized
4
2017 1171-1180]
4
dependent newly
4
immunol 2017
4
[eur immunol
4
european journal
4
issue european
4
lipids findings
4
enriched human
4
chemicals associating
4
sensitizer chemicals
4
findings light
4
self-proteins comprise
4

Similar Publications