Search our Database of Scientific Publications and Authors

I’m looking for a

    Details and Download Full Text PDF:
    The "myth" of loss of angiogenesis in systemic sclerosis: a pivotal early pathogenetic process or just a late unavoidable event?

    Arthritis Res Ther 2017 Jul 6;19(1):162. Epub 2017 Jul 6.
    Department of Experimental and Clinical Medicine, Division of Rheumatology and Scleroderma Unit, Azienda Ospedaliera Universitaria Careggi, University of Florence, Viale Pieraccini 18, 50139, Florence, Italy.
    Systemic sclerosis is considered a disease dominated by a "loss of angiogenesis", although in its early phases evidence indicates a disturbed angiogenic response only. In fact, microvascular changes are primarily due to endothelial cell injury, triggering downstream significant enlargement of the capillary in an inflammatory environment, followed by capillary rupture (microhemorrhages). Subsequent pro-angiogenic efforts lead to an aberrant angiogenesis and, eventually, to a total loss of vessel repair and regeneration (loss of angiogenesis). This clearly suggests that the pathogenetic process has a steady progression: from an early excessive pro-angiogenesis, to an aberrant microvascular regeneration, then ending with a late loss of angiogenesis. Herein, we suggest the loss of angiogenesis should not be considered as an overall "myth" characterizing systemic sclerosis but as a very late event of the vascular pathogenesis. Future research should be oriented essentially on the earlier phases dominated by excessive pro-angiogenesis and microvascular aberration.
    PDF Download - Full Text Link
    ( Please be advised that this article is hosted on an external website not affiliated with PubFacts.com)
    Source Status
    http://dx.doi.org/10.1186/s13075-017-1370-5DOI ListingPossible
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5501068PMCFound

    Similar Publications

    Mechanisms in the loss of capillaries in systemic sclerosis: angiogenesis versus vasculogenesis.
    J Cell Mol Med 2010 Jun 30;14(6A):1241-54. Epub 2010 Jan 30.
    Department of Anatomy, Histology and Forensic Medicine, University of Florence, Florence, Italy.
    Systemic sclerosis (SSc, scleroderma) is a chronic, multisystem connective tissue disorder affecting the skin and various internal organs. Although the disease is characterized by a triad of widespread microangiopathy, fibrosis and autoimmunity, increasing evidence indicates that vascular damage is a primary event in the pathogenesis of SSc. The progressive vascular injury includes persistent endothelial cell activation/damage and apoptosis, intimal thickening, delamination, vessel narrowing and obliteration. Read More
    Vasculopathy and disordered angiogenesis in selected rheumatic diseases: rheumatoid arthritis and systemic sclerosis.
    Arthritis Res Ther 2007 ;9 Suppl 2:S3
    Veterans' Hospital, and the University of Michigan Medical School, Zina Pitcher Place, Ann Arbor, Michigan 48109-2200, USA.
    Angiogenesis is important in the pathogenesis of systemic inflammatory rheumatic diseases, a family of related disorders that includes rheumatoid arthritis and systemic sclerosis. Rheumatoid arthritis is the rheumatic disease in which the role of angiogenesis has been studied most extensively. However, whereas rheumatoid arthritis is characterized by excessive angiogenesis, the situation is not as clear cut in other rheumatic diseases. Read More
    Cellular players in angiogenesis during the course of systemic sclerosis.
    Autoimmun Rev 2011 Aug 22;10(10):641-6. Epub 2011 Apr 22.
    Rheumatology, Department of Internal Medicine and Public Health, University of L'Aquila, Italy.
    Vascular endothelial injury in Systemic Sclerosis (SSc) leads to pathological changes in the blood vessels that adversely impact the physiology of many organs, resulting in chronic tissue ischemia. The response to hypoxia induces complex cellular and molecular mechanisms in the attempt to recover endothelial cell function and tissue perfusion. The progressive losses of capillaries on one hand, and the vascular remodeling of arteriolar vessels on the other, result in insufficient blood flow, causing severe and chronic hypoxia. Read More
    Scleroderma dermal microvascular endothelial cells exhibit defective response to pro-angiogenic chemokines.
    Rheumatology (Oxford) 2016 Apr 24;55(4):745-54. Epub 2015 Dec 24.
    Division of Rheumatology, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, VA Medical Service, Ann Arbor, MI, USA.
    Objectives: Angiogenesis plays a critical role in SSc (scleroderma). The aim of this study was to examine the expression of growth-regulated protein-γ (Gro-γ/CXCL3), granulocyte chemotactic protein 2 (GCP-2/CXCL6) and their receptor CXCR2 in endothelial cells (ECs) isolated from SSc skin and determine whether these cells mount an angiogenic response towards pro-angiogenic chemokines. The downstream signalling pathways as well as the pro-angiogenic transcription factor inhibitor of DNA-binding protein 1 (Id-1) were also examined. Read More