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Science 2019 11;366(6468):995-999

Biozentrum, University of Basel, CH-4056 Basel, Switzerland

The pleiotropic host resistance factor SLC11A1 (NRAMP1) defends against diverse intracellular pathogens in mammals by yet-unknown mechanisms. We compared infection of coisogenic mice with different alleles. SLC11A1 reduced replication and triggered up-regulation of uptake systems for divalent metal cations but no other stress responses. Read More

Infect Genet Evol 2019 10 20;74:103933. Epub 2019 Jun 20.

Laboratory for Immunogenetics, Central Institute for Tuberculosis, Moscow, Russia. Electronic address:

Genetic control of host susceptibility to M. avium, an important lung pathogen of immune-compromised individuals, remains incompletely defined. Apart from the slc11a1 (Nramp1) gene, which plays a pivotal role in genetic control of a few intracellular pathogens, including M. Read More

Front Med (Lausanne) 2018 16;5:213. Epub 2018 Aug 16.

Department of Immunology, National Institute of Research in Tuberculosis, Chennai, India.

Tuberculosis (TB) is still remains the major threat for human health worldwide. Several case-control, candidate-gene, family studies and genome-wide association studies (GWAS) suggested the association of host genetic factors to TB susceptibility or resistance in various ethnic populations. Moreover, these factors modulate the host immune responses to tuberculosis. Read More

Microbiome 2018 02 17;6(1):35. Epub 2018 Feb 17.

Translational Research Institute, The University of Queensland Diamantina Institute, University of Queensland, Brisbane, QLD, Australia.

Background: Dysbiosis of the gut microbiota has been implicated in the pathogenesis of many autoimmune conditions including type 1 diabetes (T1D). It is unknown whether changes in the gut microbiota observed in T1D are due to environmental drivers, genetic risk factors, or both. Here, we have performed an analysis of associations between the gut microbiota and T1D genetic risk using the non-obese diabetic (NOD) mouse model of T1D and the TwinsUK cohort. Read More

Lung 2018 02 13;196(1):125-127. Epub 2017 Nov 13.

Fariborz Maseeh Department of Mathematics and Statistics, Portland State University, Portland, OR, USA.

The incidence of three granulomatous response diseases-sarcoidosis, tuberculosis, and non-tuberculous mycobacterial pulmonary disease-differ markedly in African-Americans versus Caucasians. In reviewing a large compendium of non-cystic-fibrosis bronchiectasis, we noted that complicating infection with non-tuberculous mycobacteria was relatively infrequent among individuals of African-American descent, confirming previous observations of their inherent resistance. Disease-specific variance among African-Americans in the efficacy of their granulomatous response suggests a nexus, a mediating, immunological mechanism. Read More