Nat Commun 2021 02 22;12(1):1203. Epub 2021 Feb 22.
School of Biological Sciences, Nebraska Center for Virology, University of Nebraska, Lincoln, NE, USA.
Influenza A virus infection in swine impacts the agricultural industry in addition to its zoonotic potential. Here, we utilize epigraph, a computational algorithm, to design a universal swine H3 influenza vaccine. The epigraph hemagglutinin proteins are delivered using an Adenovirus type 5 vector and are compared to a wild type hemagglutinin and the commercial inactivated vaccine, FluSure. Read More