Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population.

Authors:
Piero Pignataro
Piero Pignataro
University of Naples Federico II
Napoli | Italy
Lucia Pezone
Lucia Pezone
CEINGE Biotecnologie Avanzate
Napoli | Italy
Danilo Franco
Danilo Franco
Gorgas Memorial Institute for Health Studies
Panamá | Panama
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Achille Iolascon
Achille Iolascon
University of Foggia
Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Mario Capasso
Mario Capasso
CEINGE Biotecnologie Avanzate

J Cardiovasc Transl Res 2017 Dec 21;10(5-6):455-458. Epub 2017 Jun 21.

Department of Molecular Medicine and Medical Biotechnology, Federico II University, Via G. Salvatore 486, 80145, Naples, Italy.

In this study, we verify the association between the rs1333049 single nucleotide polymorphism (9p21.3) within CDKN2A-CDKN2B and coronary artery disease (CAD) in an Italian population. We replicated rs1333049_G allele association with a significantly reduced risk of CAD (OR = 0.816; 95% confidence interval [0.705-0.945]; p = 0.0065) in 711 CAD patients and 755 normal healthy individuals. This effect is maintained even stratifying patients by gender and by risk factors. A significant association was found with age of CAD onset. Interestingly, we found a protective trend of association between the rs1333049_G allele and peripheral artery disease, a progressive atherosclerotic condition in which plaque builds up in the arteries that carry blood to the head, organs, and limbs (OR = 0.724; 95% CI [0.520-1.007]; p = 0.054). No genotype-phenotype association was found with more severe CAD clinical parameters. If certain genetic factors predispose individuals to adverse outcomes, the knowledge of a patient's genotype may influence clinical management.

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http://dx.doi.org/10.1007/s12265-017-9758-9DOI Listing
December 2017
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