Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis.

Molecules 2017 Jun 14;22(6). Epub 2017 Jun 14.

Department of Microbial Drugs, Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany.

Five new compounds including the glycosylated β-naphthol (, akanthol), a glycosylated pyrazine (, akanthozine), and three amide derivatives including a hydroxamic acid derivative (-) were isolated from the spider-associated fungus (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by .

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http://dx.doi.org/10.3390/molecules22060991DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6152716PMC
June 2017
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