Arch Esp Urol 2017 Jun;70(5):503-512
Hospital Carabineros de Chile. Nunoa. Santiago. Chile.
Asian Pac J Cancer Prev 2016 ;17(6):2941-6
Hospital Carabineros of Chile, Nunoa, Santiago, Chile E-mail :
Background: The limitations of total serum PSA values remain problematic, especially after an initial negative prostate biopsy. In this prospective study of Chilean men with a continued suspicion of prostate cancer due to a persistently elevated total serum PSA, abnormal digital rectal examination and initial negative prostate biopsy were compared with the use of the on-line Chun nomagram, detection of primary malignant circulating prostate cells (CPCs) and free percent PSA to predict a positive second prostate biopsy. We hypothesized that men negative for circulating prostate cells have a small risk of clinically significant prostate cancer and thus may be conservatively observed. Read More
Actas Urol Esp 2017 May 17;41(4):234-241. Epub 2017 Jan 17.
Servicio de Urología, Hospital de Carabineros de Chile, Santiago, Chile.
Introduction: The use of nomograms which include the PSA may improve the predictive power of obtaining a prostate biopsy (PB) positive for cancer. We compare the use of three on-line nomagrams with the detection of primary malignant circulating prostate cells (CPCs) to predict the results of an initial PB in men with suspicion of prostate cancer.
Methods And Patients: Consecutive men with suspicion of prostate cancer underwent a 12 core TRUS prostate biopsy; age, total serum PSA, percent free PSA, family history, ethnic origin and prostate ultrasound results were used for risk assessment using the online nomograms. Read More
Urol Oncol 2015 May 5;33(5):203.e19-25. Epub 2015 Mar 5.
Department of Urology, Hospital DIPRECA, Santiago, Chile.
Introduction: The limitations of total serum prostate-specific antigen (PSA) level values remain problematic. Nomograms may improve the predictive value of a positive prostate biopsy (PB) finding. We compare in a prospective study of Chilean men suspicious of having prostate cancer (PC), owing to an elevated total serum PSA or abnormal digital rectal examination finding or both, the use of the online Montreal nomogram for the detection of primary malignant circulating prostate cells (mCPCs) to predict a positive PB finding. Read More
Asian Pac J Cancer Prev 2015 ;16(2):601-6
Hematology, Medicine, Hospital de Carabineros de Chile, Santiago, Chile E-mail :
Background: Prostate cancer is predominately a disease of older men, with a median age of diagnosis of 68 years and 71% of cancer deaths occurring in those over 75 years of age. While prostate cancer screening is not recommended for men>70 years, fit elderly men with controlled comorbidities may have a relatively long life expectancy. We compare the use of age related PSA with the detection of primary malignant circulating prostate cells mCPCs to detect clinically significant PC in this population. Read More