Lipid-polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges.

Drug Discov Today 2017 08 8;22(8):1258-1265. Epub 2017 Jun 8.

Department of Cardiovascular Sciences, Houston Methodist Research Institute, Houston, TX, USA. Electronic address:

With rapid advances in nanomedicine, lipid-polymer hybrid nanoparticles (LPHNPs) have emerged as promising nanocarriers for several biomedical applications, including therapeutics delivery and biomedical imaging. Significant research has been dedicated to biomimetic or targeting functionalization, as well as controlled and image-guided drug-release capabilities. Despite this research, the clinical translation of LPHNP-mediated therapeutics delivery has progressed incrementally. In this review, we discuss the recent advances in and challenges to the development and application of LPHNPs, present examples to demonstrate the advantages of LPHNPs in therapeutics delivery and imaging applications, and discuss the translational obstacles to LPHNP technology.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.drudis.2017.05.015DOI Listing
August 2017
48 Reads

Publication Analysis

Top Keywords

therapeutics delivery
16
advances challenges
8
lipid-polymer hybrid
8
advantages lphnps
4
targeting functionalization
4
functionalization well
4
controlled image-guided
4
well controlled
4
biomimetic targeting
4
demonstrate advantages
4
dedicated biomimetic
4
biomedical imaging
4
discuss advances
4
imaging applications
4
imaging dedicated
4
examples demonstrate
4
delivery imaging
4
lphnps therapeutics
4
lphnps examples
4
delivery progressed
4

Similar Publications