Microbiol Spectr 2017 06;5(3)
Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710.
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Cold Spring Harb Perspect Med 2014 Nov 3;5(1):a019273. Epub 2014 Nov 3.
Division of Infectious Diseases, Duke Medical Center, Durham, North Carolina 27710.
Few among the millions of fungal species fulfill four basic conditions necessary to infect humans: high temperature tolerance, ability to invade the human host, lysis and absorption of human tissue, and resistance to the human immune system. In previously healthy individuals, invasive fungal disease is rare because animals' sophisticated immune systems evolved in constant response to fungal challenges. In contrast, fungal diseases occur frequently in immunocompromised patients. Read More
Cold Spring Harb Perspect Med 2014 Nov 6;5(4). Epub 2014 Nov 6.
Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710.
In recent years, we have seen an increase in the number of immunocompromised cohorts as a result of infections and/or medical conditions, which has resulted in an increased incidence of fungal infections. Although rare, the incidence of infections caused by fungi belonging to basal fungal lineages is also continuously increasing. Basal fungal lineages diverged at an early point during the evolution of the fungal lineage, in which, in a simplified four-phylum fungal kingdom, Zygomycota and Chytridiomycota belong to the basal fungi, distinguishing them from Ascomycota and Basidiomycota. Read More
J Antimicrob Chemother 1991 Jul;28 Suppl A:1-11
Medical Mycology Unit, University of Glasgow, UK.
The number of fungal species reported to cause disease in man is increasing rapidly. Very few of these fungi are capable of infecting a normal host. Important progress has been achieved in an understanding of fungal pathogenicity including the mechanisms of adherence to host tissues, penetration of tissues, multiplication within the host, and the interaction of fungal cells with host effector cells. Read More
Crit Rev Microbiol 2010 ;36(1):1-53
Department of Pathology, University of Iowa, Iowa City, USA.
The incidence of invasive mycoses is increasing, especially among patients who are immunocompromised or hospitalized with serious underlying diseases. Such infections may be broken into two broad categories: opportunistic and endemic. The most important agents of the opportunistic mycoses are Candida spp. Read More