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    Sclerema Neonatorum Treated Successfully with Parenteral Steroids: An Experience from a Resource Poor Country.
    Case Rep Pediatr 2017 11;2017:4836142. Epub 2017 May 11.
    Department of Pediatrics, Universal College of Medical Sciences, Bhairahawa 32900, Nepal.
    Sclerema neonatorum is a form of panniculitides characterized by diffuse hardening of subcutaneous tissue with minimal inflammation. It usually affects ill and preterm neonates. Prognosis is usually poor in many cases despite aggressive management. Various treatment modalities (antibiotics, intravenous immunoglobulin, steroids, and exchange transfusion) have been explained in literature. Steroids due to its easy availability and low cost can prove to be lifesaving in such cases, especially in resource poor countries. Here, we report a case of sclerema neonatorum in a one-week preterm baby treated successfully with parenteral steroids and antibiotics.

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    Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments.
    Cutis 2013 Aug;92(2):83-7
    Department of Dermatology, University of Alabama at Birmingham, 1530 3rd Ave S, EFH Set 414, Birmingham, AL 35294-0009, USA.
    Sclerema neonatorum (SN) is a rare neonatal panniculitis that typically develops in severely ill, preterm newborns within the first week of life and often is fatal. It usually occurs in preterm newborns with delivery complications such as respiratory distress or maternal complications such as eclampsia. Few clinical trials have been performed to address potential treatments. Read More
    Risk factors for sclerema neonatorum in preterm neonates in Bangladesh.
    Pediatr Infect Dis J 2009 May;28(5):435-8
    Department of International Health, International Center for Advancing Neonatal Health, Johns Hopkins University, Baltimore, MD, USA.
    Background: This study presents a retrospective analysis of risk factors for sclerema neonatorum in preterm neonates in Bangladesh.

    Methods: Preterm neonates admitted to Dhaka Shishu Hospital in Bangladesh were enrolled in a clinical trial to evaluate the effects of topical treatment with skin barrier-enhancing emollients on prevention of sepsis and mortality. Four hundred ninety-seven neonates were enrolled in the study and 51 (10. Read More
    Sclerema neonatorum and subcutaneous fat necrosis of the newborn in the same infant.
    Eur J Pediatr 1990 Dec;150(2):125-6
    Department of Paediatrics, Royal Free Hospital, London, UK.
    Sclerema neonatorum (SN) is a rare disease of the newborn characterised by diffuse hardening of the subcutaneous adipose tissue. The condition is distinct from the localised violacious nodules observed in subcutaneous fat necrosis of the newborn (SCFN). Both conditions were diagnosed within the first 2 weeks of life in the same infant. Read More
    Sclerema neonatorum: a review of nomenclature, clinical presentation, histological features, differential diagnoses and management.
    J Perinatol 2008 Jul 27;28(7):453-60. Epub 2008 Mar 27.
    Department of International Health, International Center for Advancing Neonatal Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
    Objective: To review published literature on sclerema neonatorum (SN) in order to clarify its clinical presentation, histological features and management compared with two other diseases: subcutaneous fat necrosis of the newborn (SCFN) and scleredema.

    Study Design: PubMed database was searched using the key words Sclerema neonatorum. A total of 55 articles from peer-reviewed journals were reviewed and summarized. Read More