JAMA Neurol 2017 Aug;74(8):1013
Department of Neurology, Ibn Sina Hospital, Sabah Medical Region, Kuwait.
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JAMA Neurol 2017 Aug;74(8):1012-1013
Department of Anesthesiology & Critical Care, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Arq Neuropsiquiatr 2000 Sep;58(3A):713-9
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brasil.
Hyperthermia, skeletal muscle rigidity, rhabdomyolysis, acidosis and multiple system insufficiency characterize malignant hyperthermia. Anaesthetic malignant hyperthermia follows halogenated volatile agents and/or depolarizing muscle relaxants utilization. Diagnosis is based on in vitro muscle contracture in response to halothane and/or caffeine exposure. Read More
Clin Neuropharmacol 2002 Jul-Aug;25(4):183-93
Department of Psychiatry, Harvard Medical School and VA Boston Healthcare System, Boston, MA, USA.
Neuroleptic malignant syndrome is a rare and potentially lethal disorder associated with the use of antipsychotic medications. Heightened vigilance on the part of clinical providers has reduced morbidity and mortality caused by this disorder over the past decade, but there is still no consensus regarding its diagnosis, pathophysiology, or treatment. Efforts to demonstrate a direct link between neuroleptic malignant syndrome and malignant hyperthermia have been unsuccessful, indicating mutually distinct etiologies despite striking clinical similarities. Read More
Encephale 1999 May-Jun;25(3):222-5
Psychiatre des Hôpitaux, Service de Psychiatrie, CHU la Timone, Marseille.
Very numerous publication in the literature suggest the probable relationship between three clinical entities: peranesthesic malignant hyperthermia (PMH), exercitional malignant hyperthermia (EMH) and neuroleptic malignant syndrome (NMS). We briefly describe the clinical history and define, as subjects of research, the personal and familial histories of neuromuscular disease of 4 of our patients having presented with neuroleptic malignant syndrome, as recommended by the European group on malignant hyperthermia, the reference contracture test on neuromuscular fibers and anatomic and cytopathological investigations of neuromuscular fibers. We compare the results for our 4 patients having presented with neuroleptic malignant syndrome and their courses. Read More