Mechanistic Role of Kinases in the Regulation of Mitochondrial Fitness.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Antonella Fiordelisi
Antonella Fiordelisi
Federico II University
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Gaetano Santulli
Gaetano Santulli
Federico II University of Naples
Italy

Adv Exp Med Biol 2017 ;982:521-528

Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy.

Mounting evidence indicates that mitochondria contain multiple phosphorylation substrates and that protein kinases translocate into mitochondria, suggesting that protein phosphorylation in this organelle could be fundamental for the regulation of its own function. Here we examine the mechanistic role of cellular kinases in the fine regulation of key mitochondrial activities, including mitochondrial quality control, fission/fusion processes, metabolism, and mitophagy.

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September 2017
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3 Citations

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