Functional Role of Mitochondria in Arrhythmogenesis.

Authors:
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy
Michele Ciccarelli
Michele Ciccarelli
University of Salerno
Fisciano | Italy
Antonella Fiordelisi
Antonella Fiordelisi
Federico II University
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy

Adv Exp Med Biol 2017 ;982:191-202

Dept. of Biomedical Advanced Sciences, Federico II University, Naples, Italy.

Growing evidence indicate that mitochondria play a functional role in arrhythmogenesis. We report here the molecular mechanisms underlying the action of these highly dynamic organelles in the regulation of cell metabolism, action potential and, overall, heart excitability. In particular, we examine the role of cardiac mitochondria in linking metabolism and cell excitability. The importance of the main mitochondrial channels is evaluated as well, including the recently identified calcium uniporter. Promises and pitfalls of potential therapeutic strategies targeting mitochondrial pathways are also assessed.

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http://dx.doi.org/10.1007/978-3-319-55330-6_10DOI Listing
September 2017
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