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Redox Biol 2021 Feb 17;41:101902. Epub 2021 Feb 17.

Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Via A Moro 2, 53100, Siena, Italy.

SARS-CoV-2 (COVID-19) infection can cause a severe respiratory distress syndrome. The risk of severe manifestations and mortality characteristically increase in the elderly and in the presence of non-COVID-19 comorbidity. We and others previously demonstrated that the low molecular weight (LMW) and protein thiol/disulfide ratio declines in human plasma with age and such decline is even more rapid in the case of inflammatory and premature aging diseases, which are also associated with the most severe complications of COVID-19 infection. Read More

Int J Med Microbiol 2021 Feb 25;311(3):151487. Epub 2021 Feb 25.

Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School and German Center for Infection Research (DZIF), Hannover, Germany. Electronic address:

The glycosylation profile of the gastrointestinal tract is an important factor mediating host-microbe interactions. Variation in these glycan structures is often mediated by blood group-related glycosyltransferases, and can lead to wide-ranging differences in susceptibility to both infectious- as well as chronic disease. In this review, we focus on the interplay between host glycosylation, the intestinal microbiota and susceptibility to gastrointestinal pathogens based on studies of two exemplary blood group-related glycosyltransferases that are conserved between mice and humans, namely FUT2 and B4GALNT2. Read More

Am J Infect Control 2021 Mar 1. Epub 2021 Mar 1.

Department of Pharmacy, Veteran Affairs Western New York Healthcare System, Buffalo, NY, USA. Electronic address:

Background: Respiratory infections are one of the most common causes of morbidity and mortality. This study examined antimicrobial susceptibility of common respiratory isolates from veterans.

Methods: Sputum culture data from the Veteran Health Administration were obtained retrospectively between January 2009 and 2019. Read More

Urology 2021 Mar 1. Epub 2021 Mar 1.

Urology Department, Fundació Puigvert, Barcelona, Spain. Electronic address:

Objective: to report on the characteristics of pregnancy in female patients with EEC (exstrophy-epispadias complex), determining in particular whether they are at higher risk of spontaneous abortion or complications.

Materials And Method: Fifty patients diagnosed with EEC and treated in a reference center for this pathology were reviewed. Those with an incomplete medical history were excluded, leaving a total of 37 women with a median follow-up of 26 years (1-48 years). Read More

Ann Am Thorac Soc 2021 Mar 4. Epub 2021 Mar 4.

Nationwide Children's Hospital, 2650, Department of Pediatrics, Division of Pediatric Critical Care Medicine, Columbus, Ohio, United States;

Rationale: Although respiratory virus testing is frequent done for critically ill infants with bronchiolitis, the prognostic value of this testing is unknown for those requiring positive pressure ventilation (PPV).

Objectives: To determine the differences in PPV utilization according to viral detection and to explore the association between viral detection and duration of PPV in critically ill children with presumed respiratory infection.

Methods: This is a retrospective cohort study in a quaternary pediatric intensive care unit from February 2014 until February 2017. Read More