Body composition estimation from selected slices: equations computed from a new semi-automatic thresholding method developed on whole-body CT scans.

PeerJ 2017 18;5:e3302. Epub 2017 May 18.

Faculty of Natural Sciences, Department of Anthropology and Human Genetics, Charles University, Prague, Czech Republic.

Background: Estimating volumes and masses of total body components is important for the study and treatment monitoring of nutrition and nutrition-related disorders, cancer, joint replacement, energy-expenditure and exercise physiology. While several equations have been offered for estimating total body components from MRI slices, no reliable and tested method exists for CT scans. For the first time, body composition data was derived from 41 high-resolution whole-body CT scans. From these data, we defined equations for estimating volumes and masses of total body AT and LT from corresponding tissue areas measured in selected CT scan slices.

Methods: We present a new semi-automatic approach to defining the density cutoff between adipose tissue (AT) and lean tissue (LT) in such material. An intra-class correlation coefficient (ICC) was used to validate the method. The equations for estimating the whole-body composition volume and mass from areas measured in selected slices were modeled with ordinary least squares (OLS) linear regressions and support vector machine regression (SVMR).

Results And Discussion: The best predictive equation for total body AT volume was based on the AT area of a single slice located between the 4th and 5th lumbar vertebrae (L4-L5) and produced lower prediction errors (|PE| = 1.86 liters, %PE = 8.77) than previous equations also based on CT scans. The LT area of the mid-thigh provided the lowest prediction errors (|PE| = 2.52 liters, %PE = 7.08) for estimating whole-body LT volume. We also present equations to predict total body AT and LT masses from a slice located at L4-L5 that resulted in reduced error compared with the previously published equations based on CT scans. The multislice SVMR predictor gave the theoretical upper limit for prediction precision of volumes and cross-validated the results.

Download full-text PDF

Source
http://dx.doi.org/10.7717/peerj.3302DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5438582PMC
May 2017
Get 20% Off Journals at LWW.com

Similar Publications

Outcomes for the first wave of hospitalised patients with COVID-19 in the South Australian context: a retrospective audit.

Intern Med J 2021 Feb;51(2):189-198

General Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia.

Background: The first case of corona virus disease (COVID-19) was detected in South Australia on 1 February 2020. The Royal Adelaide Hospital (RAH) is the state's designated quarantine hospital.

Aim: To determine the characteristics, outcomes and predictors of outcomes for hospitalised patients with coronavirus disease (COVID-19) within the RAH. Read More

View Article and Full-Text PDF
February 2021

Reversible and irreversible transgenerational effects of metal exposure on nine generations of a tropical micro-crustacean.

Environ Pollut 2021 Feb 17;276:116631. Epub 2021 Feb 17.

School of Environmental Science and Technology, Hanoi University of Science and Technology, No 1 Dai Co Viet Street, Hanoi, Viet Nam. Electronic address:

Micro-crustaceans are important grazers that control the algal blooms in eutrophic lakes. However, we know little about how these key species may be affected by long-term exposure to contaminants and when the transgenerational effects are reversible and irreversible. To address this, we investigated the effects of lead (Pb, 100 μg L) exposure on morphology and reproduction of Moina dubia for nine consecutive generations (F1-F9) in three treatments: control, Pb, and pPb (M. Read More

View Article and Full-Text PDF
February 2021

Occurrence and trophic transfer of synthetic musks in the freshwater food web of a large subtropical lake.

Ecotoxicol Environ Saf 2021 Feb 22;213:112074. Epub 2021 Feb 22.

College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China; College of Environmental Science and Engineering, North China Electric Power University, Beijing 102206, China. Electronic address:

Synthetic musks (SMs) have drawn worldwide attention, as they are persistent, bioaccumulative, and toxic to many organisms. There is not enough information on the bioaccumulation and trophodynamic behavior of SMs in freshwater food webs to reliably understand the associated ecological risks. In this study, the concentrations of six SM congeners in fifteen aquatic species from Lake Chaohu, China, was investigated. Read More

View Article and Full-Text PDF
February 2021

Increased total body extracellular-to-intracellular water ratio in community-dwelling elderly women is associated with decreased handgrip strength and gait speed.

Nutrition 2021 Jan 29;86:111175. Epub 2021 Jan 29.

Yoshinogawa Hospital, Itano-gun, Japan.

Objective: As the extracellular-to-intracellular water (ECW/ICW) ratio of the thigh is negatively associated with knee extension strength or gait speed in the elderly, an increase in the total body ECW/ICW ratio in the elderly is considered to be related to a decrease in physical function. However, these relationships have not been properly investigated. The aim of this study was to investigate the relationship of handgrip strength and gait speed with the total body ECW/ICW ratio in community-dwelling elderly women. Read More

View Article and Full-Text PDF
January 2021

A multidisciplinary approach to the evaluation of the effects of foraging on landfills on white stork nestlings.

Sci Total Environ 2021 Feb 10;775:145197. Epub 2021 Feb 10.

SaBio Research Group, Instituto de Investigación en Recursos Cinegéticos IREC, (CSIC-UCLM-JCCM), Ciudad Real, Spain.

The use of landfills as foraging areas by white storks (Ciconia ciconia) is a recent well-known behaviour. While several studies have highlighted positive effects at a populational level others suggest that the presence of pollutants, pathogens and the lower presence of antioxidants in the food could pose a health risk for individuals. The objective of this study was to evaluate potential effects of the use of landfills as a food resource on the physiology and health of white stork nestlings, by a multidisciplinary approach based on the analysis of nutritional status, body condition, blood parameters, oxidative stress balance and the presence of pathogens. Read More

View Article and Full-Text PDF
February 2021