BMC Biotechnol 2017 05 18;17(1):45. Epub 2017 May 18.
Department of Physics, Ryerson University, 350 Victoria Street Toronto, Ontario, M5B 2K3, Canada.
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Int J Mol Sci 2017 Jul 25;18(8). Epub 2017 Jul 25.
Imaging Division, University Medical Center Utrecht, Utrecht, 3584 CX, The Netherland.
Microbubbles-assisted ultrasound (USMB) has shown promise in improving local drug delivery. The formation of transient membrane pores and endocytosis are reported to be enhanced by USMB, and they contribute to cellular drug uptake. Exocytosis also seems to be linked to endocytosis upon USMB treatment. Read More
PLoS One 2016 8;11(6):e0156754. Epub 2016 Jun 8.
Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada.
Drug delivery to tumors is limited by several factors, including drug permeability of the target cell plasma membrane. Ultrasound in combination with microbubbles (USMB) is a promising strategy to overcome these limitations. USMB treatment elicits enhanced cellular uptake of materials such as drugs, in part as a result of sheer stress and formation of transient membrane pores. Read More
Ultrasound Med Biol 2015 Jul 27;41(7):1913-26. Epub 2015 Apr 27.
Centre de Biophysique Moléculaire, CNRS UPR4301, Orléans, France.
Microbubble oscillation at specific ultrasound settings leads to permeabilization of surrounding cells. This phenomenon, referred to as sonoporation, allows for the in vitro and in vivo delivery of extracellular molecules, including plasmid DNA. To date, the biological and physical mechanisms underlying this phenomenon are not fully understood. Read More
J Control Release 2016 09 29;238:157-165. Epub 2016 Jul 29.
Imaging Division, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address:
The possibility to enhance drug delivery by using ultrasound in combination with microbubbles (USMB) is extensively studied. So far, these studies have focused on the delivery and efficacy of a single drug, e.g. Read More