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Rev Med Chil 2020 Dec;148(12):1781-1786

Department of Pediatric Endocrinology, UC Christus Health Center, Pontificia Universidad Católica de Chile, Chile.

Background: Osteogenesis imperfecta (OI) is a rare group of genetic disorders affecting connective tissue, with consequent bone fragility, frequent fractures and skeletal deformity. Depending on the type, patients can have blue sclera, dentinogenesis imperfecta, and hearing loss.

Aim: To determine the frequency, type and audiometric characteristics of hearing loss in a group of patients with OI. Read More

Inorg Chem 2021 Apr 12. Epub 2021 Apr 12.

Department of Chemistry, University of Houston, 3585 Cullen Boulevard, Room 112, Houston, Texas 77204-5003, United States.

In this paper, we report a series of six neutral, blue-phosphorescent cyclometalated iridium complexes of the type Ir(C^Y)(CNAr)(CN). The cyclometalating ligands in these compounds (C^Y) are either aryl-substituted 1,2,4-triazole or NHC ligands, known to produce complexes with blue phosphorescence. These cyclometalating ligands are paired with π-acidic, strongly σ-donating cyano and aryl isocyanide (CNAr) ancillary ligands, the hypothesis being that these ancillary ligands would destabilize the higher-lying ligand-field (-) excited states, allowing efficient blue photoluminescence. Read More

Mol Cell Biochem 2021 Apr 12. Epub 2021 Apr 12.

Grupo de investigación en Biología celular y funcional e ingeniería de biomoléculas, Universidad Antonio Nariño-Sede Circunvalar. Cra, 3 Este # 47A - 15, Bl 5, Bogotá, Colombia.

Obesity and type 2 diabetes (T2D) are growing health problems associated with a loss of insulin sensitivity. Both conditions arise from a long-term energy imbalance, and frequently, lifestyle measures can be useful in its prevention, including physical activity and a healthy diet. Pancreatic β-cells are determinant nutrient sensors that participate in energetic homeostasis needs. Read More

Equine Vet J 2021 Apr 12. Epub 2021 Apr 12.

The Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield, Hertfordshire, AL9 7TA, UK.

Background: Exercise induced pulmonary haemorrhage (EIPH) is an important condition of horses performing high intensity exercise, with reported prevalence among racehorses of up to 95%, based on the detection of blood on tracheobronchoscopy. Previously identified risk factors include age, sex, season, race type, years spent in racing and lower airway inflammation.

Objectives: To estimate the prevalence of EIPH in British National Hunt racehorses as indicated by two outcome measures: presence of tracheal blood on tracheobronchoscopy, and presence of moderate-large (significant) proportions of haemosiderophages in tracheal wash (TW) fluid; and to identify training-related risk factors for these indicators of EIPH. Read More

IBRO Neurosci Rep 2021 Jun 6;10:119-129. Epub 2021 Feb 6.

Department of Cell Biology and Molecular Medicine, University of Szeged, Szeged, Hungary.

Morphological and functional characterizations of cultured microglia are essential for the improved understanding of their roles in neuronal health and disease. Although some studies (phenotype analysis, phagocytosis) can be carried out in mixed or microglia-enriched cultures, in others (gene expression) pure microglia must be used. If the use of genetically modified microglial cells is not feasible, isolation of resident microglia from nervous tissue must be carried out. Read More