Nat Rev Mol Cell Biol 2017 06 10;18(6):339-340. Epub 2017 May 10.
Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia.
RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the distribution, location and dynamics of RNA modifications.