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PLoS Comput Biol 2021 Apr 9;17(4):e1008860. Epub 2021 Apr 9.

School of Energy Science and Engineering, Indian Institute of Technology Kharagpur, West Bengal, India.

The COVID-19 pandemic is posing an unprecedented threat to the whole world. In this regard, it is absolutely imperative to understand the mechanism of metabolic reprogramming of host human cells by SARS-CoV-2. A better understanding of the metabolic alterations would aid in design of better therapeutics to deal with COVID-19 pandemic. Read More

Eur Geriatr Med 2021 Apr 9. Epub 2021 Apr 9.

Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.

Purpose: To describe the objectives, methods and expected impact of an international consortium (iKASCADE) whose purpose is to improve drug safety for older adults by addressing prescribing cascades through a sex and gender lens.

Methods: To create a comprehensive, internationally relevant inventory of prescribing cascades affecting older adults, the consortium has created a modified Delphi procedure where international experts in prescribing and managing pharmacotherapy for older adults will rank a list of prescribing cascades as to their clinical importance. We will use administrative and clinical data on older adults to evaluate the frequency of prescribing cascades by sex internationally, in the hospital, long-term care and community settings. Read More

J Physiol Biochem 2021 Apr 9. Epub 2021 Apr 9.

Clinical Medical Research Institute, First Affiliated Hospital of Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, People's Republic of China.

PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to hold dual metabolic and nonmetabolic roles. Working as both a pyruvate kinase with catalytic activity and a protein kinase that phosphorylates its substrates, PKM2 stands at the crossroads of glycolysis and tumor growth. Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Mar;33(3):381-384

Department of Medical Intensive Care Unit, General Hospital of Southern Theatre Command; Branch of National Clinical Research Center for Geriatric Diseases (Chinese PLA General Hospital), Guangzhou Key Laboratory of Geriatric Infection and Organ Function Support, Guangzhou 510010, Guangdong, China. Corresponding author: Chen Rui, Email:

Over the last decade, chronic critically ill (CCI) has emerged as an epidemic in intensive care unit (ICU) survivors worldwide. Advances in ICU technology and implementation of care bundles has significantly decreased early deaths of critically ill patients, and have allowed them to survive previously lethal multiple organ failure (MOF). However, more and more survivors leave persistent low grade organ dysfunctions, depend on continues organ support, need to stay in ICU, and become CCI patients. Read More

Circ Res 2021 Apr 9. Epub 2021 Apr 9.

Internal Medicine, VCU Medical Center, UNITED STATES.

Intestinal Alkaline Phosphatase (IAP) is secreted by enterocytes and is present on the apical surface. It not only detoxifies bacterial endotoxin lipopolysaccharide (LPS) in the gut lumen and limits intestinal inflammation but also restricts translocation of LPS into systemic circulation. Diet-induced intestinal barrier dysfunction and subsequent development of metabolic endotoxemia seen in diabetes and heart disease is associated with reduced IAP levels. Read More