NewProt - a protein engineering portal.

Protein Eng Des Sel 2017 06;30(6):441-447

CMBI, Radboud University Medical Centre, Geert Grooteplein Zuid 26-28, 6525 GA Nijmegen, The Netherlands.

The NewProt protein engineering portal is a one-stop-shop for in silico protein engineering. It gives access to a large number of servers that compute a wide variety of protein structure characteristics supporting work on the modification of proteins through the introduction of (multiple) point mutations. The results can be inspected through multiple visualizers. The HOPE software is included to indicate mutations with possible undesired side effects. The Hotspot Wizard software is embedded for the design of mutations that modify a proteins' activity, specificity, or stability. The NewProt portal is freely accessible at http://newprot.cmbi.umcn.nl/ and http://newprot.fluidops.net/.

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http://dx.doi.org/10.1093/protein/gzx024DOI Listing
June 2017
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References

(Supplied by CrossRef)

Science 1973

PLoS. Comput. Biol. 2015

PLoS Comput. Biol. 2014

Nature 2012

2009

Nucleic Acids Res. 2005

BMC Bioinformatics 2013

Proteins 2006

BMC. Bioinformatics. 2007

Protein Sci. 2000

Bioinformatics. 2009

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