Maternal choline status during pregnancy, but not that of betaine, is related to antenatal mental well-being: The growing up in Singapore toward healthy outcomes cohort.

Authors:
Phaik Ling Quah
Phaik Ling Quah
Singapore Institute for Clinical Sciences (SICS)
Seang Mei Saw
Seang Mei Saw
Saw Swee Hock School of Public Health
Singapore | Singapore
Keith M Godfrey
Keith M Godfrey
University of Southampton
Highfield | United Kingdom
Yap Seng Chong
Yap Seng Chong
Singapore Institute for Clinical Sciences
Singapore
Michael J Meaney
Michael J Meaney
Singapore Institute for Clinical Sciences
Singapore
Helen Chen
Helen Chen
KK Women's and Children's Hospital
Singapore

Depress Anxiety 2017 10 4;34(10):877-887. Epub 2017 May 4.

Singapore Institute for Clinical Science, Agency for Science, Technology and Research, Singapore, Singapore.

Background: Choline and betaine status have previously been associated with symptoms of depression. However, the relation of maternal plasma choline and betaine concentrations in pregnancy to peripartum maternal mood is unknown.

Methods: Maternal plasma choline and betaine concentrations (μmol/L) were measured at 26-28 weeks gestation in the Growing Up in Singapore Toward healthy Outcomes (GUSTO) mother-offspring cohort. Participants completed the State-Trait Anxiety Inventory (STAI) and Edinburgh Postnatal Depression Scale (EDPS) at 26-28 weeks gestation (n = 949) and at 3 months postnatal (n = 689): higher scores are indicative of more symptoms of anxiety and depression. Multivariate linear regression models were used to estimate the association of choline and betaine with ante- and postnatal mental well-being adjusting for covariates.

Results: Mean (SD) antenatal plasma choline and betaine concentrations were 9.2 μmol/L (1.6) and 13.1 μmol/L (2.7), respectively. Plasma choline concentrations were positively associated with antenatal depressive (β = .24 EPDS score [95% CI: 0.05-0.43] per μmol/L] and anxiety symptoms (β = .46 STAI-state score [95% CI: 0.03-0.88] per μmol/L) adjusting for covariates. Plasma betaine concentrations were not associated with antenatal depression or anxiety symptoms. No associations were observed between pregnancy choline or betaine and postnatal mental well-being.

Conclusion: This study suggests that higher maternal plasma choline status during pregnancy is associated with more symptoms of antenatal depression and anxiety, whereas plasma betaine concentrations showed no associations. No associations were observed for postnatal mental well-being. Prospective studies are required to replicate these findings and further examine the direction of causality and possible biological mechanisms.

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http://dx.doi.org/10.1002/da.22637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5553109PMC
October 2017
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References

(Supplied by CrossRef)
Choline in anxiety and depression: The Hordaland Health Study
Bjelland et al.
American Journal of Clinical Nutrition 2009
Choline and cholinergic neurons
Blusztajn et al.
Science 1983
Choline and betaine food sources and intakes in Taiwanese
Chu et al.
Asia Pacific Journal of Clinical Nutrition 2012

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