Characterization of Sgo1 expression in developing and adult mouse.

Gene Expr Patterns 2017 11 29;25-26:36-45. Epub 2017 Apr 29.

Cardiovascular Genetics, Department of Pediatrics, CHU Sainte-Justine, Montreal, QC, Canada; Université de Montréal, Montreal, QC, Canada. Electronic address:

SGO1 has been characterized in its function in correct cell division and its role in centrosome cohesion in the nucleus. However, its organ-specific maturation-related expression pattern in vivo remains largely uncharacterized. Here, we show clear SGO1 expression in post-developmental neuronal cells and cytoplasmic localisation in nucleated cells with a transgenic mice model and immunohistochemistry of wild type mice. We demonstrate extranuclear expression of Sgo1 in the developing heart and gut, which have been shown to be dysregulated in humans with homozygous SGO1 mutation. Additionally, we show Sgo1 expression in select population of retinal cells in developing and post-developmental retina. Our expression analysis strongly suggests that the function of SGO1 goes beyond its well characterized role in cell division.

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http://dx.doi.org/10.1016/j.gep.2017.04.004DOI Listing
November 2017
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