Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells and by varying counter anions.

Chem Sci 2016 Dec 18;7(12):7013-7019. Epub 2016 Jul 18.

Beijing National Laboratory for Molecular Sciences , CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems , Institute of Chemistry , Chinese Academy of Sciences , Beijing , 100190 , China . Email: ; Email: ; Email:

Chemotherapeutics specifically targeting cancer cells without damaging healthy cells is the long-awaited goal of cancer treatment. In this paper, a series of nanoparticles (NanoTPES ) assembled from pyridinium-substituted tetraphenylethylene salts were synthesized and investigated both and for this purpose. By changing the counter anions, NanoTPES exhibit tunable emission colors, sizes and surface charges. NanoTPES and with tetraphenyl borate and tetra(4-chlorophenyl) borate as the respective anions selectively imaged and targeted mitochondria in cancer cells. Accordingly, these two nanoparticles specifically kill cancer cells with minimal effect on normal cells. Such selective cytotoxicity was attributed to the change of membrane potential and inhibition of ATP synthesis in the mitochondria of cancer cells. Furthermore, both NanoTPES and exhibited efficient tumor accumulation and tumor growth inhibition , with negligible systemic toxicity.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c6sc02395aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355829PMC
December 2016
71 Reads

Publication Analysis

Top Keywords

cancer cells
20
selective cytotoxicity
8
counter anions
8
tetraphenylethylene salts
8
pyridinium-substituted tetraphenylethylene
8
mitochondria cancer
8
cells
7
cancer
6
borate respective
4
tetra4-chlorophenyl borate
4
respective anions
4
selectively imaged
4
cells nanoparticles
4
nanoparticles kill
4
targeted mitochondria
4
imaged targeted
4
borate tetra4-chlorophenyl
4
anions selectively
4
nanotpes tetraphenyl
4
nanotpes exhibit
4

References

(Supplied by CrossRef)

Szakács et al.
Nat. Rev. Drug Discovery 2006

Wang et al.
Chem. Soc. Rev. 2013

Gu et al.
Nat. Rev. Cancer 2016

Danhiera et al.
J. Controlled Release 2010

Bertrand et al.
Adv. Drug Delivery Rev. 2014

Petros et al.
Nat. Rev. Drug Discovery 2010

Maeda et al.
J. Controlled Release 2000

Lim et al.
Chem. Rev. 2015

Allena et al.
Adv. Drug Delivery Rev. 2013

Kolemen et al.
Angew. Chem., Int. Ed. 2016

Riedinger et al.
J. Am. Chem. Soc. 2015

Similar Publications