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Food Chem 2021 Feb 9;350:129242. Epub 2021 Feb 9.

Department of Analytical Chemistry and Pollutants, Faculty of Chemistry and Petroleum Sciences, Shahid Beheshti University, Tehran, Iran.

Herein, an electrospun polyacrylonitrile/nickel-based metal-organic framework nanocomposite (PAN/Ni-MOF) coating on a stainless steel wire was synthesized and employed as a novel nanosorbent for headspace solid-phase microextraction (HS-SPME) of organophosphorus pesticides (OPPs), diazinon (DIZ), and chlorpyrifos (CPS) from the diverse aqueous media followed by corona discharge ion mobility spectrometry (CD-IMS). Under the optimum experimental conditions, the calibration plots were linear in the range of 1.0-250. Read More

Med Chem 2021 Feb 8. Epub 2021 Feb 8.

Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Bijnor-Sisendi Road, Near CRPF Base Camp, Sarojini Nagar, Lucknow, Uttar Pradesh 226301, . India.

Aim: To synthesize and evaluate the fused heterocyclic imidazopyridine oxime as a reactivator against paraoxon inhibited acetylcholinesterase.

Background: Organophosphorus compounds (OPs) include parathion, malathion, chlorpyrifos, monocrotophos, and diazinon which are commonly used in agriculture for enhancing agricultural productivity via killing crop-damaging pests. However, people may get exposed to OPs pesticides unintentionally/intentionally via ingestion, inhalation or dermal. Read More

J Sci Food Agric 2021 Feb 7. Epub 2021 Feb 7.

Pesticide Analytical Laboratory, Pesticide Research and Environmental Toxicology Section, Entomology Division, Bangladesh Agricultural Research Institute, Gazipur, Bangladesh.

Background: Variability of pesticide residues in food item plays a key role for the evaluation of consumer food safety. However, variability factors (VFs) derived from the large size fruit crops are still scarce. Therefore, the present work was aimed to quantify pesticide residues and to estimate VFs in large size fruit crops of mango and guava. Read More

Sci Total Environ 2021 Jan 17;769:144563. Epub 2021 Jan 17.

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), 18012 Granada, Spain; CIBER de Epidemiología y Salud Pública (CIBERESP), Spain; Biomedical Research Center (CIBM), University of Granada, 18100 Granada, Spain. Electronic address:

Objective: To examine the association between urinary metabolites of organophosphate (OP) pesticides and serum concentrations of thyroid and reproductive hormones in male adolescents and to assess the potential effect of interactions between OP pesticides and paraoxonase 1 (PON1) polymorphisms on hormone levels.

Methods: Study subjects (N = 117) were male 16- to 17-year-olds from the Environment and Childhood (INMA)-Granada cohort in Spain. Concentrations of 3,5,6-trichloro-2-pyridinol (TCPy), a metabolite of chlorpyrifos/chlorpyrifos-methyl, 2-isopropyl-6-methyl-4-pyrimidinol (IMPy), a metabolite of diazinon, and diethylthiophosphate (DETP) and diethyldithiophosphate (DEDTP), non-specific metabolites of OP pesticides, were measured in a spot urine sample from each subject and adjusted for creatinine. Read More

Environ Sci Technol 2021 Feb 20;55(3):1585-1593. Epub 2021 Jan 20.

Department of Plant and Environmental Sciences, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg, Denmark.

Hydrolysis catalyzed by general esterases (GEs) is the most efficient route for hydrolyzation of pyrethroid insecticides. Organophosphate (OP) and carbamate (CB) insecticides are known to inhibit GEs in addition to acetylcholinesterase (AChE), which is their main target. We hypothesize that synergies can be induced by OPs and CBs when mixed with pyrethroids, due to their inhibition of GE-dependent detoxification of pyrethroids. Read More