The Pretreatment Neutrophil-to-Lymphocyte Ratio is a Prognostic Determinant of T3-4 Hypopharyngeal Squamous Cell Carcinoma.

Ann Surg Oncol 2017 Jul 21;24(7):1980-1988. Epub 2017 Apr 21.

Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan.

Objective: This study aimed to investigate the clinicopathological factors that influence recurrence and survival in patients who undergo operations for T3-4 hypopharyngeal squamous cell carcinomas (SCCs).

Materials And Methods: One hundred and five patients who underwent surgery between 2001 and 2008 for advanced hypopharyngeal SCCs were consecutively enrolled and reviewed.

Results: The pretreatment neutrophil-to-lymphocyte ratio (NLR; median 3.22, range 0.62-46.50) was associated with disease recurrence and patient survival. A difference in the 5-year cumulative disease recurrence rate between patients with high (≥3.22) and low (<3.22) NLRs was significant (60.4 and 36.5%, respectively; p = 0.004). A multivariate analysis confirmed that an NLR ≥3.22 was an independent indicator of a poor prognosis for advanced hypopharyngeal SCC, as per the following parameters: overall survival (hazard ratio [HR] 2.53, 95% confidence interval [CI] 1.48-4.30, p = 0.001), disease-specific survival (HR 2.45, 95% CI 1.38-4.34, p = 0.002), and disease-free survival (HR 2.18, 95% CI 1.24-3.83, p = 0.007). Additional prognostic factors per the survival analyses included lymph node density, surgical margin, lymphovascular invasion, and perineural invasion.

Conclusions: An NLR ≥3.22 is associated with a higher risk of disease recurrence and poor survival in patients with T3-4 hypopharyngeal SCCs. We propose the use of the NLR to broaden the current TNM staging system; the development of a more effective treatment protocol for patients with high NLRs will be essential.

Download full-text PDF

Source
http://dx.doi.org/10.1245/s10434-017-5865-8DOI Listing
July 2017
11 Reads

Publication Analysis

Top Keywords

hypopharyngeal squamous
8
t3-4 hypopharyngeal
8
squamous cell
8
disease recurrence
8
neutrophil-to-lymphocyte ratio
8
pretreatment neutrophil-to-lymphocyte
8
patients underwent
4
recurrence patient
4
underwent surgery
4
methods patients
4
patient survival
4
surgery 2001
4
sccsmaterials methods
4
operations t3-4
4
undergo operations
4
patients undergo
4
difference 5-year
4
cell carcinomas
4
survival difference
4
carcinomas sccsmaterials
4

References

(Supplied by CrossRef)

YC Huang et al.
Oral Oncol. 2016

JG Spector et al.
Laryngoscope. 2001

G Omura et al.
Int J Clin Oncol. 2015

MR Posner et al.
N Engl J Med. 2007

JP Pignon et al.
Lancet 2000

YH Joo et al.
Ann Surg Oncol. 2015

T Taguchi et al.
Cancer Chemother Pharmacol. 2014

TF Pezier et al.
Eur Arch Otorhinolaryngol. 2014

Y Yu et al.
Chin Med J. 2013

CJ Yang et al.
J Surg Oncol. 2013

PY Chu et al.
Ann Otol Rhinol Laryngol. 2008

Similar Publications