Fructose Consumption in the Development of Obesity and the Effects of Different Protocols of Physical Exercise on the Hepatic Metabolism.

Authors:
Dennys Esper Cintra
Dennys Esper Cintra
School of Applied Sciences
Oxford | United States
Jose Rodrigo Pauli
Jose Rodrigo Pauli
School of Applied Sciences
Oxford | United States
Eduardo Rochete Ropelle
Eduardo Rochete Ropelle
School of Applied Sciences
Brazil

Nutrients 2017 Apr 20;9(4). Epub 2017 Apr 20.

Laboratory of Molecular Biology of Exercise (LaBMEx), School of Applied Science, University of Campinas, 13484-350 Limeira, Brazil.

Fructose consumption has been growing exponentially and, concomitant with this, the increase in the incidence of obesity and associated complications has followed the same behavior. Studies indicate that fructose may be a carbohydrate with greater obesogenic potential than other sugars. In this context, the liver seems to be a key organ for understanding the deleterious health effects promoted by fructose consumption. Fructose promotes complications in glucose metabolism, accumulation of triacylglycerol in the hepatocytes, and alterations in the lipid profile, which, associated with an inflammatory response and alterations in the redox state, will imply a systemic picture of insulin resistance. However, physical exercise has been indicated for the treatment of several chronic diseases. In this review, we show how each exercise protocol (aerobic, strength, or a combination of both) promote improvements in the obesogenic state created by fructose consumption as an improvement in the serum and liver lipid profile (high-density lipoprotein (HDL) increase and decrease triglyceride (TG) and low-density lipoprotein (LDL) levels) and a reduction of markers of inflammation caused by an excess of fructose. Therefore, it is concluded that the practice of aerobic physical exercise, strength training, or a combination of both is essential for attenuating the complications developed by the consumption of fructose.

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http://dx.doi.org/10.3390/nu9040405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409744PMC

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April 2017
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References

(Supplied by CrossRef)
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease
Johnson et al.
Am. J. Clin. Nutr. 2007

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