Pubfacts - Scientific Publication Data
  • Categories
  • |
  • Journals
  • |
  • Authors
  • Login
  • Categories
  • Journals

Search Our Scientific Publications & Authors

Publications
  • Publications
  • Authors
find publications by category +
Translate page:

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface.

Authors:
HaoRan Tang Leo Leung Grazia Saturno Amaya Viros Duncan Smith Gianpiero Di Leva Eamonn Morrison Dan Niculescu-Duvaz Filipa Lopes Louise Johnson Nathalie Dhomen Caroline Springer Richard Marais

Nat Commun 2017 04 18;8:14909. Epub 2017 Apr 18.

Molecular Oncology Group, Cancer Research UK Manchester Institute, University of Manchester, Manchester M20 4BX, UK.

Lysyl oxidase (LOX) remodels the tumour microenvironment by cross-linking the extracellular matrix. LOX overexpression is associated with poor cancer outcomes. Here, we find that LOX regulates the epidermal growth factor receptor (EGFR) to drive tumour progression. We show that LOX regulates EGFR by suppressing TGFβ1 signalling through the secreted protease HTRA1. This increases the expression of Matrilin2 (MATN2), an EGF-like domain-containing protein that traps EGFR at the cell surface to facilitate its activation by EGF. We describe a pharmacological inhibitor of LOX, CCT365623, which disrupts EGFR cell surface retention and delays the growth of primary and metastatic tumour cells in vivo. Thus, we show that LOX regulates EGFR cell surface retention to drive tumour progression, and we validate the therapeutic potential of inhibiting this pathway with the small molecule inhibitor CCT365623.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms14909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399287PMC
April 2017

Publication Analysis

Top Keywords

cell surface
16
lox regulates
12
tumour progression
12
egfr cell
12
regulates egfr
8
surface retention
8
drive tumour
8
lysyl oxidase
8
lox
6
egfr
5
tumour
5
matn2 egf-like
4
surface facilitate
4
facilitate activation
4
egf-like domain-containing
4
domain-containing protein
4
matrilin2 matn2
4
protein traps
4
traps egfr
4
htra1 increases
4

Altmetric Statistics


Show full details
85 Total Shares
2 Facebook Pages
2 Blogs
29 News Outlets
41 Tweets
77 Citations

Similar Publications

Influence of water content and cell disruption on lipid extraction using subcritical dimethyl ether in wet microalgae.

Authors:
Quan Wang Kazuyuki Oshita Masaki Takaoka Kenji Shiota

Bioresour Technol 2021 Feb 27;329:124892. Epub 2021 Feb 27.

Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan.

Subcritical dimethyl ether, a green solvent, was used to extract lipids from microalgae. The effect of the water content on the process was firstly investigated. Secondly, microalgal samples were subjected to five cell disruptions, and the effects on raw lipid and fatty acid methyl ester, and its profile were evaluated. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Description of Candidatus Mesopelagibacter carboxydoxydans and Candidatus Anoxipelagibacter denitrificans: Nitrate-reducing SAR11 genera that dominate mesopelagic and anoxic marine zones.

Authors:
Carlos A Ruiz-Perez Anthony D Bertagnolli Despina Tsementzi Tanja Woyke Frank J Stewart Konstantinos T Konstantinidis

Syst Appl Microbiol 2021 Feb 17;44(2):126185. Epub 2021 Feb 17.

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA 30332, USA; School of Civil and Environmental Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA; Center for Bioinformatics and Computational Genomics, Georgia Institute of Technology, Atlanta, GA 30332, USA. Electronic address:

The diverse and ubiquitous members of the SAR11 lineage (Alphaproteobacteria) represent up to 30-40% of the surface and mesopelagic oceanic microbial communities. However, the molecular and ecological mechanisms that differentiate closely related, yet distinct, SAR11 members that often co-occur under similar environmental conditions remain speculative. Recently, two mesopelagic and oxygen minimum zone (OMZ)-associated subclades of SAR11 (Ic and IIa. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Heterogeneous populations from in vitro cultures of antigen presenting cells in pigs.

Authors:
Myriam Pujol Efrain Guzman Sergio Montaner-Tarbes Maria Montoya

Vet Immunol Immunopathol 2021 Feb 25;234:110215. Epub 2021 Feb 25.

The Pirbright Institute, Pirbright, Woking, GU24 0NF, UK; Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, Madrid, Spain. Electronic address:

Dendritic cells (DCs) are the most potent antigen presenting cells (APCs). Because of the difficulty in obtaining these cells directly from tissues, different sources of DCs are frequently used for in vitro experimentation and many of their biological and functional characteristics were studied using these systems. Until recently, it was assumed that specific culture conditions polarized the differentiation of either DCs or macrophages (Macs); however, it was shown that some DC culture systems in other species generate heterogeneous cell populations that can be identified according to their CD11c and MHC class II (MHC-II) expression. Read More

View Article and Full-Text PDF
February 2021
Similar Publications

Evaluation of polymer choice on immunogenicity of chitosan coated PLGA NPs with surface-adsorbed pneumococcal protein antigen PspA4Pro.

Authors:
Kan Kaneko Eliane N Miyaji Viviane M Gonçalves Daniela M Ferreira Carla Solórzano Ronan MacLoughlin Imran Saleem

Int J Pharm 2021 Mar 3:120407. Epub 2021 Mar 3.

School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, UK. Electronic address:

Polymeric nanoparticles (NPs) are recognized as potential delivery vehicles for vaccines. PLGA is a biocompatible polymer synonymous with polymeric NPs, which can be coated with other polymers such as chitosan that has intrinsic adjuvant properties as well as mucoadhesive properties. Numerous modifications and variations exist for PLGA and chitosan, which can influence the NP characteristics and the resulting immunogenicity. Read More

View Article and Full-Text PDF
March 2021
Similar Publications

Evaluation of human umbilical vein endothelial cells growth onto heparin-modified electrospun vascular grafts.

Authors:
Pablo C Caracciolo Patricia Diaz-Rodriguez Inés Ardao David Moreira Florencia Montini-Ballarin Gustavo A Abraham Angel Concheiro Carmen Alvarez-Lorenzo

Int J Biol Macromol 2021 Mar 3. Epub 2021 Mar 3.

Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.

One of the main challenges of cardiovascular tissue engineering is the development of bioresorbable and compliant small-diameter vascular grafts (SDVG) for patients where autologous grafts are not an option. In this work, electrospun bilayered bioresorbable SDVG based on blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) were prepared and evaluated. The inner layer of these SDVG was surface-modified with heparin, following a methodology involving PHD urethane functional groups. Read More

View Article and Full-Text PDF
March 2021
Similar Publications
© 2021 PubFacts.
  • About PubFacts
  • Privacy Policy
  • Sitemap