Curr Opin Cardiol 2021 Feb 16. Epub 2021 Feb 16.
Clinical Department of Internal Medicine and Specialistic Units, Azienda Ospedaliera, Universitaria, and University Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli' IRCCS-SDN, Istituto di Ricovero e Cura a Carattere, Scientifico, Naples Department of Cardiac Surgery, Azienda Ospedaliera Universitaria San Giovanni di Dio e Ruggi d'Aragona, Salerno Department of Precision Medicine, University of Campania 'Luigi Vanvitelli', Naples Chair of Cardiac Surgery, Department of Cardiothoracic Surgery, Istituto Clinico Sant'Ambrogio; University of Milan, Milan, Italy.
Purpose Of Review: Cardiovascular diseases (CVDs) are typically caused by multifactorial events including mutations in a large number of genes. Epigenetic-derived modifications in the cells are normal but can be amended by aging, lifestyle, and exposure to toxic substances. Major epigenetic modifications are DNA methylation, histone modification, chromatin remodeling as well as the noncoding RNAs. Read More