Activation of Notch pathway is linked with epithelial-mesenchymal transition in prostate cancer cells.

Cell Cycle 2017 May 7;16(10):999-1007. Epub 2017 Apr 7.

a Department of Urology , Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China.

Notch signaling has been reported to play an essential role in tumorigenesis. Several studies have suggested that Notch receptors could be oncoproteins or tumor suppressors in different types of human cancers. Emerging evidence has suggested that Notch pathway regulates cell growth, apoptosis, cell cycle, and metastasis. In the current study, we explore whether Notch-1 could regulate the cell invasion and migration as well as EMT (epithelial-mesenchymal transition) in prostate cancer cells. We found that overexpression of Notch-1 enhanced cell migration and invasion in PC-3 cells. However, downregulation of Notch-1 retarded cell migration and invasion in prostate cancer cells. Importantly, we observed that overexpression of Notch-1 led to EMT in PC-3 cells. Notably, we found that EMT-type cells are associated with EMT markers change and cancer stem cell phenotype. Taken together, we concluded that downregulation of Notch-1 could be a promising approach for inhibition of invasion in prostate cancer cells, which could be useful for the treatment of metastatic prostate cancer.

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Source
http://dx.doi.org/10.1080/15384101.2017.1312237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5462088PMC
May 2017
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