Molecular characterization of lysyl oxidase-mediated extracellular matrix remodeling during mouse decidualization.

FEBS Lett 2017 05 28;591(10):1394-1407. Epub 2017 Apr 28.

College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.

The establishment of decidualization is a prerequisite of successful pregnancy. Lysyl oxidase (Lox) is a copper-containing amine oxidase which catalyzes cross-linking of collagen and elastin in the ECM. Lox is expressed in the subluminal stroma surrounding the implanting blastocyst on day 5 of pregnancy. From days 6 to 8, the signals for Lox mRNA and protein are strongly detected in the decidual cells. The expression of Lox is under the control of estrogen via the GSK-3β/β-catenin/c-myc pathway. Dtprp is decreased by the inhibition of Lox activity. Furthermore, the inhibition of Lox activity decreases stromal cell migration and embryo adhesion. Our findings highlight the crucial role of Lox in endometrial stromal cells and deepen our understanding of decidualization.

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http://dx.doi.org/10.1002/1873-3468.12645DOI Listing
May 2017
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