Pelvic inflammatory disease and the risk of ovarian cancer: a meta-analysis.

Cancer Causes Control 2017 May 24;28(5):415-428. Epub 2017 Mar 24.

Faculty of Medicine, School of Public Health and Primary Care, The Chinese University of Hong Kong, Room 508, 5/F, School of Public Health, Prince of Wales Hospital, Shatin, N.T., Hong Kong, China.

Purpose: Previous studies on pelvic inflammatory disease (PID) and the risk of ovarian cancer have found inconsistent results. We performed an updated meta-analysis to summarize the evidence of this association.

Methods: PubMed, Embase, and ISI web of science databases were searched through October 2016 for studies that investigated the PID and ovarian cancer association. Summary risk estimates were calculated using random-effects meta-analysis.

Result: Thirteen studies were eligible for analysis, which included six cohort studies and seven case-control studies. PID was associated with an increased risk of ovarian cancer overall [relative risk (RR) 1.24, 95% CI 1.06-1.44; I  = 58.8%]. In analyses stratified by race, a significant positive association was observed in studies conducted among Asian women (RR 1.69, 95% CI 1.22-2.34; I  = 0%), but marginally significant among Caucasians (RR 1.18, 95% CI 1.00-1.39; I  = 60.7%).Risk estimates were elevated in both cohort (RR1.32; 95% CI 1.05-1.66; I  = 64.7%) and case-control studies (RR 1.17; 95% CI 0.93-1.49; I  = 57.6%), albeit not statistically significant in case-control studies.

Conclusions: Our results suggested that PID might be a potential risk factor of ovarian cancer, with pronounced associations among Asian women. Large and well-designed studies with objective assessment methods, such as hospital records, are needed to confirm the findings of this meta-analysis.

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http://dx.doi.org/10.1007/s10552-017-0873-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5616173PMC
May 2017
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