The mechanisms of air pollution and particulate matter in cardiovascular diseases.

Authors:
Antonella Fiordelisi
Antonella Fiordelisi
Federico II University
Prisco Piscitelli
Prisco Piscitelli
University of Florence
Italy
Bruno Trimarco
Bruno Trimarco
Federico II University
Napoli | Italy
Enrico Coscioni
Enrico Coscioni
San Giovanni di Dio e Ruggì D'Aragona Hospital
Prof. Guido Iaccarino, MD, PhD
Prof. Guido Iaccarino, MD, PhD
Federico II University of Naples
Full Professor of Applied Medical Science and Technology
Cardiology
Napoli, Campania | Italy
Daniela Sorriento
Daniela Sorriento
Department of Clinical Medicine
Italy

Heart Fail Rev 2017 05;22(3):337-347

Department of Advanced Biomedical Sciences, University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy.

Clinical and epidemiological studies demonstrate that short- and long-term exposure to air pollution increases mortality due to respiratory and cardiovascular diseases. Given the increased industrialization and the increased sources of pollutants (i.e., cars exhaust emissions, cigarette smoke, industry emissions, burning of fossil fuels, incineration of garbage), air pollution has become a key public health issue to solve. Among pollutants, the particulate matter (PM) is a mixture of solid and liquid particles which differently affects human health depending on their size (i.e., PM with a diameter <10 μm reach the lung and PM with a diameter <2.5 μm penetrate deeper into the lung). In particular, the acute exposure to PM and PM increases the rate of cardiovascular deaths. Thus, appropriate interventions to reduce air pollution may promote great benefits to public health by reducing the risk of cardiovascular diseases. Several biological mechanisms have been identified to date which could be responsible for PM-dependent adverse cardiovascular outcomes. Indeed, the exposure to PM and PM induces sustained oxidative stress and inflammation. PM is also able to increase autonomic nervous system activation. Some potential therapeutic approaches have been tested both in pre-clinical and clinical studies, based on the intake of antioxidants from dietary or by pharmacological administration. Studies are still in progress to increase the knowledge of PM activation of intracellular pathways and propose new strategies of intervention.

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10741-017-9606-7DOI Listing
May 2017
10 Reads
7 Citations
3.790 Impact Factor

Publication Analysis

Top Keywords

air pollution
12
cardiovascular diseases
8
particulate matter
8
emissions burning
4
industry emissions
4
burning fossil
4
fuels incineration
4
garbage air
4
incineration garbage
4
fossil fuels
4
cigarette smoke
4
sources pollutants
4
increased sources
4
industrialization increased
4
pollutants cars
4
cars exhaust
4
pollution key
4
emissions cigarette
4
smoke industry
4
health issue
4

References

(Supplied by CrossRef)
Article in Lancet
B Brunekreef et al.
Lancet 2002
Article in J R Soc Med
I Blumenthal et al.
J R Soc Med 2001
Article in The American journal of the medical sciences
TM Chen et al.
The American journal of the medical sciences 2007
Article in EXS
PB Tchounwou et al.
EXS 2012
Article in J Air Waste Manage Assoc
O Garcia-Algar et al.
J Air Waste Manage Assoc 2003
Article in Environ Health Perspect
T Wainman et al.
Environ Health Perspect 2000
Article in N Engl J Med
KA Miller et al.
N Engl J Med 2007
Article in JAMA
CA Pope 3rd et al.
JAMA 2002
Article in Circulation
RD Brook et al.
Circulation 2004
Article in Futur Cardiol
MR Miller et al.
Futur Cardiol 2012
Article in Journal of environmental science and health Part C, Environmental carcinogenesis & ecotoxicology reviews
A Valavanidis et al.
Journal of environmental science and health Part C, Environmental carcinogenesis & ecotoxicology reviews 2008

Similar Publications