Secondary Metabolites from the Marine-Derived Fungus Dichotomomyces sp. L-8 and Their Cytotoxic Activity.

Molecules 2017 Mar 11;22(3). Epub 2017 Mar 11.

School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.

Bioassay-guided isolation of the secondary metabolites from the fungus . L-8 associated with the soft coral led to the discovery of two new compounds, dichotones A and B ( and ), together with four known compounds including dichotocejpin C (), bis--norgliovictin (), bassiatin () and (3,6)-bassiatin (). The structures of these compounds were determined by 1D, 2D NMR and mass spectrometry. (3,6)bassiatin () displayed significant cytotoxic activities against the human breast cancer cell line MDA-MB-435 and the human lung cancer cell line Calu3 with IC values of 7.34 ± 0.20 and 14.54 ± 0.01 μM, respectively, while bassiatin (), the diastereomer of compound , was not cytotoxic.

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http://dx.doi.org/10.3390/molecules22030444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6155177PMC
March 2017
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References

(Supplied by CrossRef)
The bioactive natural products and biological activities of the red sea soft coral Sarcophyton: A review
Hussien et al.
Res. J. Pharm. Biol. Chem. Sci. 2015

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