Electro-echocardiographic Indices to Predict Cardiac Resynchronization Therapy Non-response on Non-ischemic Cardiomyopathy.

Sci Rep 2017 03 10;7:44009. Epub 2017 Mar 10.

Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, PR China.

Cardiac resynchronization therapy (CRT) threw lights on heart failure treatment, however, parts of patients showed nonresponse to CRT. Unfortunately, it lacks effective parameters to predict CRT non-response. In present study, we try to seek effective electro-echocardiographic predictors on CRT non-response. This is a retrospective study to review a total of 227 patients of dyssynchronous heart failure underwent CRT implantation. Logistic analysis was performed between CRT responders and CRT non-responders. The primary outcome was the occurrence of improved left ventricular ejection fraction 1 year after CRT implantation. We concluded that LVEDV > 255 mL (OR = 2.236; 95% CI, 1.016-4.923) rather than LVESV > 160 mL (OR = 1.18; 95% CI, 0.544-2.56) and TpTe/QTc > 0.203 (OR = 5.206; 95% CI, 1.89-14.34) significantly predicted CRT non-response. Oppositely, S wave > 5.7 cm/s (OR = 0.242; 95% CI, 0.089-0.657), E/A > 1 (OR = 0.211; 95% CI, 0.079-0.566), E'/A' > 1 (OR = 0.054; 95% CI, 0.017-0.172), CLBBB (OR = 0.141; 95% CI, 0.048-0.409), and QRS duration >160 ms (OR = 0.52; 95% CI, 0.305-0.922) surprisingly predicted low-probability of CRT non-response.

Download full-text PDF

Source
http://dx.doi.org/10.1038/srep44009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5345096PMC
March 2017

Publication Analysis

Top Keywords

crt non-response
16
crt
10
heart failure
8
cardiac resynchronization
8
95%
8
resynchronization therapy
8
crt implantation
8
non-response
5
e'/a' > 1 or = 0054
4
primary outcome
4
ventricular ejection
4
non-responders primary
4
outcome occurrence
4
or = 0054 95%
4
occurrence improved
4
0017-0172 clbbb
4
95% 0017-0172
4
improved left
4
left ventricular
4
crt responders
4

Similar Publications