G1 cyclins protect pluripotency.

Nat Cell Biol 2017 03;19(3):149-150

Stanford University Medical Center, Departments of Pediatrics and Genetics, Stanford Medical School, SIM1 Building, 265 Campus Drive, Stanford, California 94305, USA.

G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

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March 2017
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