Cryptococcus gattii molecular type VGII infection associated with lung disease in a goat.

BMC Vet Res 2017 Feb 7;13(1):41. Epub 2017 Feb 7.

Departamento de Patologia, Serviço de Patologia Animal - Hospital Veterinário (HOVET), Faculdade de Medicina Veterinária e Zootecnia da Universidade de São Paulo (FMVZ-USP), Av. Prof. Dr. Orlando Marques de Paiva 87, Cidade Universitária, São Paulo, SP, 05508-270, Brazil.

Background: Cryptococcus gattii-induced cryptococcosis is an emerging infectious disease of humans and animals with worldwide distribution and public health importance due to its significant morbidity and mortality rate. The present study aimed to report a case of pulmonary infection by C. gattii molecular type VGII in State of São Paulo, Brazil.

Case Presentation: A 5-year-old goat showing intermittent dry cough, ruminal tympany, anorexia, fever, tachycardia and tachypnea was presented for necropsy at the Veterinary Hospital of the School of Veterinary Medicine and Animal Sciences, São Paulo University, São Paulo, Brazil. Postmortem examination revealed numerous 2.0-6.0 cm diameter yellow gelatinous pulmonary masses. Tissues were evaluated by a combination of pathological, mycological, and molecular diagnostic techniques. Microscopically, pneumonia granulomatous, multifocal to coalescing, moderate, with many intralesional carminophilic yeasts was observed. The immunohistochemistry and mycological culture confirmed Cryptococcus spp. Internal transcribed spacers and orotidine monophosphate pyrophosphorylase nucleotide differentiation demonstrated that the isolate corresponds to the C. gattii VGII molecular subtype.

Conclusions: To our knowledge, this is the first report of a pulmonary infection in a goat linked to C. gattii molecular type VGII in Southeastern Brazil. Our findings emphasize the need for an active surveillance program for human and animal new infections to improve the current public health policies due to expansion of the epidemiological niche of this important microorganism.

Download full-text PDF

Source Listing

Still can't find the full text of the article?

We can help you send a request to the authors directly.
February 2017
11 Reads

Publication Analysis

Top Keywords

gattii molecular
molecular type
são paulo
type vgii
pulmonary infection
public health
mycological molecular
molecular diagnostic
pathological mycological
diagnostic techniques
observed immunohistochemistry
tissues evaluated
evaluated combination
combination pathological
techniques microscopically
pneumonia granulomatous
moderate intralesional
intralesional carminophilic
yeasts observed


(Supplied by CrossRef)
Article in Cold Spring Harb Perspect Med
KJ Kwon-Chung et al.
Cold Spring Harb Perspect Med 2014
Article in Mem Inst Oswaldo Cruz
MLM Soares et al.
Mem Inst Oswaldo Cruz 2011
Article in Can Vet J
C Duncan et al.
Can Vet J 2006
Article in Vet Ophthalmol
EO Ropstad et al.
Vet Ophthalmol 2011
Article in Revta Iberoam Micol
G Castellá et al.
Revta Iberoam Micol 2008
Article in Curr Opin Microb
SM Brown et al.
Curr Opin Microb 2007
Article in Revista del Patronato de Biología Animal
B Aller et al.
Revista del Patronato de Biología Animal 1971
Article in J Clin Microb
T Baró et al.
J Clin Microb 1998
Article in Vet Pathol
M Gutiérrez et al.
Vet Pathol 1999
Article in Med Mycol
A Villarroel et al.
Med Mycol 2012
Article in Vet Rec
K Robson et al.
Vet Rec 2011

Similar Publications