Troponin T levels associated with genetic variants in NOTCH2 and MTNR1B in women with psychosis.

Psychiatry Res 2017 Apr 20;250:217-220. Epub 2017 Jan 20.

Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden; Department of Adult Psychiatry, PRIMA Barn och Vuxenpsykiatri AB, Stockholm, Sweden; Centre for Family Medicine, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.

Psychosis patients have increased prevalence of metabolic disorders, which increase the risk for cardiovascular disease. Elevated troponin T level is an early biomarker of cardiovascular damage. We tested for association between troponin T levels and genetic risk variants of elevated blood glucose level in psychosis. Glucose and troponin T levels correlated positively. MTNR1B rs10830963 and NOTCH2 rs10923931 associated with troponin T levels in women, adjusted for glucose levels. These findings may indicate metabolic genetic influences on troponin T levels among women with psychosis.

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http://dx.doi.org/10.1016/j.psychres.2017.01.030DOI Listing
April 2017
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