Mechanisms of Regulatory B cell Function in Autoimmune and Inflammatory Diseases beyond IL-10.

Authors:
Avijit Ray, PhD
Avijit Ray, PhD
AbbVie
Senior Scientist II
Immunology, Immuno-oncology, Autoimmunity and Inflammation, Immune tolerance
North Chicago, IL | United States
Bonnie N Dittel
Bonnie N Dittel
Blood Research Institute

J Clin Med 2017 Jan 23;6(1). Epub 2017 Jan 23.

Blood Center of Wisconsin, Blood Research Institute, Milwaukee, WI 53226, USA.

In the past two decades it has become clear that in addition to antigen presentation and antibody production B cells play prominent roles in immune regulation. While B cell-derived IL-10 has garnered much attention, B cells also effectively regulate inflammation by a variety of IL-10-independent mechanisms. B cell regulation has been studied in both autoimmune and inflammatory diseases. While collectively called regulatory B cells (Breg), no definitive phenotype has emerged for B cells with regulatory potential. This has made their study challenging and thus unique B cell regulatory mechanisms have emerged in a disease-dependent manner. Thus to harness the therapeutic potential of Breg, further studies are needed to understand how they emerge and are induced to evoke their regulatory activities.

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Source
http://dx.doi.org/10.3390/jcm6010012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5294965PMC

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January 2017
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