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Blood Purif 2021 Mar 1:1-6. Epub 2021 Mar 1.

ProKidney, Grand Cayman, George Town, Cayman Islands.

Background: Advanced cell therapies with autologous, homologous cells show promise to affect reparative and restorative changes in the chronic kidney disease (CKD) nephron. We present our protocol and preliminary analysis of an IRB-approved, phase I single-group, open-label trial that tests the safety and efficacy of Renal Autologous Cell Therapy (REACT; NCT04115345) in adults with congenital anomalies of the kidney and urinary tract (CAKUT).

Methods: Adults with surgically corrected CAKUT and CKD stages 3 and 4 signed an informed consent and served as their "own" baseline control. Read More

Curr Opin Genet Dev 2021 Feb 26;69:42-47. Epub 2021 Feb 26.

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California San Diego, La Jolla, CA, USA. Electronic address:

Naturalists leading up to the early 20th century were captivated by the diversity of limb form and function and described its development in a variety of species. The advent of discoveries in genetics followed by molecular biology led to focused efforts in few 'model' species, namely mouse and chicken, to understand conserved mechanisms of limb axis specification and development of the musculoskeletal system. 'Non-traditional' species largely fell by the wayside until their recent resurgence into the spotlight with advances in next-generation sequencing technologies (NGS). Read More

Drug Alcohol Depend 2021 Feb 21;221:108642. Epub 2021 Feb 21.

Department of Psychiatry and Human Behavior, Department of Behavioral and Social Sciences, Center for Alcohol and Addiction Studies, Brown University, Box G-S121-4, Providence, RI, 02912, United States. Electronic address:

Aim: We sought to elucidate whether stress, peers, and in vivo (i.e., direct) alcohol cues elicit alcohol craving in daily life among adolescents and to test whether individual variation in working memory function and biological sex alters these associations. Read More

Physiol Behav 2021 Feb 26:113372. Epub 2021 Feb 26.

Instituto de Neurociências e Comportamento, INeC, Ribeirão Preto, SP, Brazil; Physiology, Pharmacology & Neuroscience, University of Bristol, Bristol BS8 1TD, UK.

It is unclear whether all animal models of anxiety-like states developed using males are appropriate for use in females. In females, tests involving a learning component might be influenced not only by estrous cycle stage on the test day but also by the stage during the conditioning process. We used two tests - conditioned freezing (CF) and fear potentiated startle (FPS) to compare responsiveness of male rats and females conditioned and/or tested in proestrus (P) or late diestrus (LD). Read More

J Speech Lang Hear Res 2021 Mar 1:1-13. Epub 2021 Mar 1.

Speech and Language Pathology Unit, Department of Health and Rehabilitation, Sahlgrenska Academy at the University of Gothenburg, Sweden.

Purpose Deep brain stimulation (DBS) is often successful in alleviating motor symptoms of essential tremor (ET); however, DBS may also induce adverse speech effects. The caudal zona incerta (cZi) is a promising DBS target for tremor, but less is known about the consequences of cZi DBS for speech. This preliminary study examined how habitual cZi DBS and cZi stimulation at high amplitudes may affect speech function in persons with ET. Read More