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Clin Res Hepatol Gastroenterol 2021 Feb 23;45(4):101519. Epub 2021 Feb 23.

Department of Gastroenterology and Hepatology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán", Av. Vasco de Quiroga 15, colonia Belisario Domínguez Sección XVI, Tlalpan, 14080 Mexico City, Mexico. Electronic address:

Introduction: Alpha-1 antitrypsin deficiency (AATD) is a risk factor for liver disease. PASD-positive inclusions have been found unexpectedly in approximately 10% of liver explants in patients with no previous diagnosis of AATD, particularly, in patients with non-alcoholic steatohepatitis (NASH), supporting a synergistic mechanism of liver injury between AATD and environmental factors. We aimed to determine the clinical characteristics of mestizo patients in which AATD was diagnosed before or after liver transplantation. Read More

Clin Res Hepatol Gastroenterol 2021 Jan 28;45(4):101639. Epub 2021 Jan 28.

AP-HP, Hôpital Paul Brousse, Centre Hépato-Biliaire, INSERM, Unité 1193, Villejuif, France.

Background: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in organ transplant recipients remains limited. The aim of this registry-based observational study was to report the characteristics and clinical outcomes of liver transplant (LT) recipients included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19.

Methods: COVID-19 was diagnosed in patients who had a positive PCR assay for SARS-CoV-2 or in presence of typical lung lesions on imaging or specific SARS-CoV-2 antibodies. Read More

Transplant Rev (Orlando) 2021 Feb 5;35(2):100606. Epub 2021 Feb 5.

Department of Hepatobiliary and Pancreatic Surgery, The Center for Integrated Oncology and Precision Medicine, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China. Electronic address:

Liver transplantation (LT), one of the radical methods of treating liver cancer, has brought new hope for the treatment of unresectable liver cancer. Currently, patients who meet transplant criteria can achieve a favorable prognosis, but those who exceed transplant criteria tend not to have very satisfactory outcomes. For patients whose tumor burden exceeds the transplant criteria, downstaging treatment is a promising method to reduce tumor burden to within the transplant criteria that may lead to good posttransplant survival. Read More

Hepatology 2021 Feb 26. Epub 2021 Feb 26.

Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas, TX, USA.

Background & Aims: Patients with acute liver injury or failure (ALI/ALF) experience bleeding complications uncommonly despite an abnormal hemostatic profile. Rotational thromboelastometry (ROTEM), which assesses clot formation in whole blood, was employed to determine the nature of abnormal hemostasis and whether it contributes to bleeding events, illness severity, or survival.

Approach & Results: 200 patients were recruited from sites of the ALF Study Group. Read More

Hepatology 2021 Feb 26. Epub 2021 Feb 26.

Department of Gastroenterology and Hepatology, Ghent University - Ghent University Hospital, Ghent, Belgium.

Pulmonary disease in liver cirrhosis and portal hypertension constitutes a challenging clinical scenario and may have important implications with regard to prognosis, liver transplantation (LT) candidacy and post-LT outcome. Pre-LT evaluation should include adequate screening for pulmonary diseases that may occur concomitantly with liver disease as well as for those that may arise as a complication of end-stage liver disease and portal hypertension, as either may jeopardize safe LT and successful outcome. It is key to discriminate those patients who would benefit from LT, especially pulmonary disorders that have been reported to resolve post-LT and are considered 'pulmonary indications' for transplant, from those who are at increased mortality risk and in whom LT is contraindicated. Read More