Wiley Interdiscip Rev Syst Biol Med 2017 03 23;9(2). Epub 2016 Dec 23.
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA.
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J Neurophysiol 2017 Oct 19;118(4):2194-2215. Epub 2017 Jul 19.
Lawrence D. Longo Center for Perinatal Biology, Division of Physiology, School of Medicine, Loma Linda University, Loma Linda, California; and.
How sensory information influences the dynamics of rhythm generation varies across systems, and general principles for understanding this aspect of motor control are lacking. Determining the origin of respiratory rhythm generation is challenging because the mechanisms in a central circuit considered in isolation may be different from those in the intact organism. We analyze a closed-loop respiratory control model incorporating a central pattern generator (CPG), the Butera-Rinzel-Smith (BRS) model, together with lung mechanics, oxygen handling, and chemosensory components. Read More
Prog Brain Res 2014 ;212:253-75
Heart Research Institute, Newtown, New South Wales, Australia.
Swallowing and breathing utilize common muscles and an anatomical passage: the pharynx. The risk of aspiration of ingested material is minimized not only by the laryngeal adduction of the vocal folds and laryngeal elevation but also by the precise coordination of swallows with breathing. Namely, swallows: (1) are preferentially initiated in the postinspiratory/expiratory phase, (2) are accompanied by a brief apnea, and (3) are often followed by an expiration and delay of the next breath. Read More
Trends Neurosci 2013 Mar 17;36(3):152-62. Epub 2012 Dec 17.
Cellular and Systems Neurobiology Section, National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), Bethesda, MD, USA.
Breathing movements in mammals are driven by rhythmic neural activity generated within spatially and functionally organized brainstem neural circuits comprising the respiratory central pattern generator (CPG). This rhythmic activity provides homeostatic regulation of gases in blood and tissues and integrates breathing with other motor acts. We review new insights into the spatial-functional organization of key neural microcircuits of this CPG from recent multidisciplinary experimental and computational studies. Read More
J Theor Biol 2008 Apr 28;251(3):480-97. Epub 2007 Dec 28.
Institute of Information and Mathematical Sciences, Massey University, Albany, Private Bag 102-904, North Shore Mail Centre, Auckland, New Zealand.
A new model for aspects of the control of respiration in mammals has been developed. The model integrates a reduced representation of the brainstem respiratory neural controller together with peripheral gas exchange and transport mechanisms. The neural controller consists of two components. Read More