Brain tau deposition linked to systemic causes of death in normal elderly.

Neurobiol Aging 2017 02 24;50:163-166. Epub 2016 Nov 24.

Department of Neurology, Mayo Clinic, Rochester, MN, USA.

The relationship between causes of death and 4 major neurodegenerative brain proteins (beta-amyloid, tau, alpha-synuclein, and the TAR DNA-binding protein of 43 kDa (TDP-43) were assessed in 94 cognitively normal elderly participants that died without a neurodegenerative disease. There was an association between tau and causes of death (p = 0.01). Tau in the brain was associated with a reduced likelihood of dying from systemic cancers (p = 0.046), and with an increased likelihood of dying from pulmonary (p = 0.03) and gastrointestinal (p = 0.049) diseases. There were no associations between beta-amyloid, alpha-synuclein, or TDP-43 and causes of death. Tau deposition in the brain may have a relationship with systemic causes of death, including cancer, in the cognitively normal elderly.

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http://dx.doi.org/10.1016/j.neurobiolaging.2016.11.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5221486PMC
February 2017
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