Single-Nucleotide Polymorphisms and Cancer Risk, Tumor Recurrence, or Survival of Head and Neck Cancer Patients.

Oncology 2017 21;92(3):161-169. Epub 2016 Dec 21.

Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Objective: This paper aims at studying the influence of single-nucleotide polymorphisms (SNPs) on cancer risk, tumor recurrence, and survival in head and neck (H&N) cancer patients.

Methods: A total of 45 SNPs in 41 genes were investigated. A total of 174 Caucasian H&N cancer patients and 245 healthy blood donors were enrolled in the study.

Results: Ten SNPs were associated with H&N cancer risk, but the identified SNPs differed among males and females. Some of the SNPs were related to immune response genes. The immune response gene SNPs were also related to survival. In particular, we noted that the tumor necrosis factor alpha (TNFα) rs1800629 could have an influence on cancer risk, tumor recurrence as well as survival.

Conclusion: Genetic variation of the TNFα rs1800629 might be useful as a biomarker in clinical decision-making since it was found to be related to cancer risk, tumor recurrence, and survival of H&N cancer patients.

Download full-text PDF

Source
http://dx.doi.org/10.1159/000452278DOI Listing
March 2017
2.420 Impact Factor

Publication Analysis

Top Keywords

cancer risk
20
risk tumor
16
tumor recurrence
16
h&n cancer
16
recurrence survival
12
cancer patients
12
cancer
9
tnfα rs1800629
8
survival head
8
head neck
8
immune response
8
single-nucleotide polymorphisms
8
snps
6
tumor
5
risk
5
males females
4
differed males
4
response genes
4
genes immune
4
snps differed
4

Similar Publications