A large-scale genome-wide association and meta-analysis identified four novel susceptibility loci for leprosy.

Nat Commun 2016 12 15;7:13760. Epub 2016 Dec 15.

Shandong Provincial Institute of Dermatology and Venereology, Shandong Academy of Medical Sciences, Jinan, Shandong 250000, China.

Leprosy, a chronic infectious disease, results from the uncultivable pathogen Mycobacterium leprae (M. leprae), and usually progresses to peripheral neuropathy and permanent progressive deformity if not treated. Previously published genetic studies have identified 18 gene/loci significantly associated with leprosy at the genome-wide significant level. However as a complex disease, only a small proportion of leprosy risk could be explained by those gene/loci. To further identify more susceptibility gene/loci, we hereby performed a three-stage GWAS comprising 8,156 leprosy patients and 15,610 controls of Chinese ancestry. Four novel loci were identified including rs6807915 on 3p25.2 (P=1.94 × 10, OR=0.89), rs4720118 on 7p14.3 (P=3.85 × 10, OR=1.16), rs55894533 on 8p23.1 (P=5.07 × 10, OR=1.15) and rs10100465 on 8q24.11 (P=2.85 × 10, OR=0.85). Altogether, these findings have provided new insight and significantly expanded our understanding of the genetic basis of leprosy.

Download full-text PDF

Source
http://dx.doi.org/10.1038/ncomms13760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5172377PMC
December 2016
63 Reads

Publication Analysis

Top Keywords

leprosy
6
comprising 8156
4
gwas comprising
4
three-stage gwas
4
gene/loci performed
4
performed three-stage
4
8156 leprosy
4
patients 15610
4
ancestry novel
4
novel loci
4
chinese ancestry
4
controls chinese
4
15610 controls
4
leprosy patients
4
susceptibility gene/loci
4
level complex
4
complex disease
4
genome-wide level
4
leprosy genome-wide
4
associated leprosy
4

Similar Publications