Antibacterial Activity of Silver Nanoparticles and Their Combination with Essential Oil and Methanol Extract.

Jundishapur J Microbiol 2016 Oct 17;9(10):e36070. Epub 2016 Sep 17.

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, IR Iran; Department of Pharmacology & Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University (IAUPS), Tehran, IR Iran.

Background: Against a variety of antimicrobial resistant pathogens, the scientists attempted substitution of antimicrobial medicine with various nanoparticles and plant-based antibacterial substances.

Objectives: The aim of this study was to assess the antibacterial effects of silver nanoparticles solely and in combination with essential oil and methanolic extract on some photogenic bacteria.

Methods: Minimum inhibitory concentrations (MICs) and fractional inhibitory concentrations (FICs) of plant essential oil, methanolic extract, and silver nanoparticles against bacteria were evaluated using the broth microdilution method and check board microtiter assays.

Results: The results of the experiment showed that the MIC and minimal bacterial concentration (MBC) values of Ag-NPs against all strains were in the range of 15.625 - 500 µg/mL, and values for the essential oil and plant extract were in the range of 1.56 - 100 mg/mL.

Conclusions: Silver nanoparticles were observed to have additive effects with essential oil against and . The obtained results suggest the need for further investigations of the antibacterial effects of the combination of silver nanoparticles with other plant extracts and essential oils.

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Source
http://dx.doi.org/10.5812/jjm.36070DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5136444PMC
October 2016
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