Pregnancy outcome and blood biomarkers

Tania T Herrera, Jillian L Garcia, Gabrielle B Britton

Overview

A complete review about all the information on biomarkers that predict pregnancies complications in maternal obesity

Summary

Our findings show that there are only no more than two or three biomarkers that could have strong impact as predictors of complications in maternal obesity

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Author Comments

Dr. Tania T Herrera, MD
Dr. Tania T Herrera, MD
Punta Pacifica Hospital John Hopkins affiliated
Maternal Fetal Medicine consultant
Obstetrics and Gynecology
Panama city, Panama | Panama
Obese pregnant women are more likely to have elevated blood pressure, gestational diabetes and babies with birth complications. Dr. Tania T Herrera, MD

Resources

Data about Obesity in Pregnancy
https://www.cdc.gov/nchs/data/nvsr/nvsr65/nvsr65_06.pdf
Maternal Obesity Series
https://www.thelancet.com/series/maternal-obesity

Blood-based biomarkers of adverse perinatal outcomes in maternal obesity.

Authors:
Dr. Tania T Herrera, MD
Dr. Tania T Herrera, MD
Punta Pacifica Hospital John Hopkins affiliated
Maternal Fetal Medicine consultant
Obstetrics and Gynecology
Panama city, Panama | Panama

J Matern Fetal Neonatal Med 2017 Dec 12;30(24):2991-2997. Epub 2017 Jan 12.

c Centro de Neurociencias y Unidad de Investigación Clínica , Instituto de Investigaciones Científicas y Servicios de Alta Tecnología (INDICASAT AIP) , Clayton , Panamá.

Objective: Increasing maternal weight has been shown to predict adverse perinatal outcome, including increases in the relative risk of fetal death, stillbirth, neonatal death, perinatal death and infant death. In order to better understand the pathophysiological factors associated with obesity during pregnancy, the role of biomarkers associated with adverse outcomes in obese pregnant women is under investigation. The purpose of this review study was to examine potential biomarkers that could serve as effective screening strategies in obese pregnant women to reduce fetal and neonatal morbidity, as well as maternal morbidity.

Methods: Electronic databases (Pubmed, Embase) were searched for previously published research studies that investigated biomarkers associated with perinatal outcomes in obese pregnant women and the putative mechanisms underlying biomarker effects on pregnancy outcomes.

Results: It is evident that while several biomarkers predict perinatal complications in obese pregnant women, none fulfilled the criteria to be considered clinically useful.

Conclusion: There is a critical need for reliable blood-based biomarkers associated with an increased risk of adverse perinatal outcomes in obese pregnant women.

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Source
http://dx.doi.org/10.1080/14767058.2016.1271406DOI Listing
December 2017
164 Reads
1.500 Impact Factor

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References

(Supplied by CrossRef)

Mazaki-Tovi S et al.
J Perinat Med 2009

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