Biodegradable Magnetic Silica@Iron Oxide Nanovectors with Ultra-Large Mesopores for High Protein Loading, Magnetothermal Release, and Delivery.

Authors:
Haneen Omar
Haneen Omar
Smart Hybrid Materials Laboratory
Dr. Jonas G Croissant, PhD
Dr. Jonas G Croissant, PhD
University of New Mexico, Chemical & Biological Engineering
Research Assistant Professor
Chemistry, Materials Science
Albuquerque, New Mexico | United States
Kholod Alamoudi
Kholod Alamoudi
Smart Hybrid Materials Laboratory
Shahad Alsaiari
Shahad Alsaiari
Smart Hybrid Materials (SHMs) Laboratory
Ibrahim Alradwan
Ibrahim Alradwan
Life Science and Environment Research Institute
Bethesda | United States
Majed A Majrashi
Majed A Majrashi
National Center for Biotechnology
Dalaver H Anjum
Dalaver H Anjum
King Abdullah University of Science and Technology (KAUST)
Saudi Arabia
Patricia Martins
Patricia Martins
Institute of Physical Activity and Sports Sciences

J Control Release 2017 08 29;259:187-194. Epub 2016 Nov 29.

Smart Hybrid Materials Laboratory, Advanced Membranes and Porous Materials Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.. Electronic address:

The delivery of large cargos of diameter above 15nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~534kDa). Half of the content of the nanovectors was based with iron oxide nanophases which allowed the rapid biodegradation of the carrier in fetal bovine serum and a magnetic responsiveness. The nanovectors released large protein cargos in aqueous solution under acidic pH or magnetic stimuli. The delivery of large proteins was then autonomously achieved in cancer cells via the silica-iron oxide nanovectors, which is thus a promising for biomedical applications.

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http://dx.doi.org/10.1016/j.jconrel.2016.11.032DOI Listing

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August 2017
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