Two Cases of Chromomycosis Identified by Molecular Phylogenetic Analysis.

Authors:
Takayo Mitomo
Takayo Mitomo
Kyorin University School of Medicine
Yukiko Ushigome
Yukiko Ushigome
School of Medicine
Salt Lake City | United States
Tomoo Fukuda
Tomoo Fukuda
Kyorin University
Yoko Kano
Yoko Kano
Kyorin University School of Medicine
Tetsuo Shiohara
Tetsuo Shiohara
Kyorin University School of Medicine

Med Mycol J 2016 ;57(4):J133-J139

Department of Dermatology, Kyorin University School of Medicine.

Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. While there are many kinds of dematiaceous fungi, the major etiologic agent is Fonsecaea pedrosoi, which to date has accounted for 90% of chromoblastomycosis cases. The genus Fonsecaea has recently been assessed via rRNA ITS sequence analysis, and species have been classified into F. pedrosoi, F. monophora, and others. We encountered two cases of chromomycosis that had developed on facial and upper arm areas. Neither of the etiologic agents could be identified through morphological examination under a microscope; however, F. monophora was confirmed using molecular phylogenetic analysis. Indeed, molecular phylogenetic analysis has revealed that the etiologic agents in many reported cases of F. pedrosoi infections were actually F. monophora. This suggests that it is now necessary to reconsider the classification of genus Fonsecaea.

Download full-text PDF

Source
http://dx.doi.org/10.3314/mmj.15-00026DOI Listing
July 2017
6 Reads

Publication Analysis

Top Keywords

phylogenetic analysis
12
molecular phylogenetic
12
genus fonsecaea
8
etiologic agents
8
cases chromomycosis
8
dematiaceous fungi
8
cases
4
fonsecaea pedrosoi
4
monophora confirmed
4
pedrosoi accounted
4
accounted 90%
4
cases genus
4
chromoblastomycosis cases
4
90% chromoblastomycosis
4
agent fonsecaea
4
major etiologic
4
phaeohyphomycosis kinds
4
mycetoma phaeohyphomycosis
4
analysis revealed
4
revealed etiologic
4

Similar Publications

Molecular identification of chromoblastomycosis clinical isolates in Guangdong.

Med Mycol 2017 Nov;55(8):851-858

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.

Chromoblastomycosis is a chronic fungal infection of the skin and subcutaneous tissue. The most common etiologic agent encountered in Southern China is from the genus Fonsecaea. Fonsecaea species are often misidentified due to indistinct morphology features; furthermore, recent taxonomy revision was done on the fungi genus. Read More

View Article
November 2017

Fonsecaea nubica sp. nov, a new agent of human chromoblastomycosis revealed using molecular data.

Med Mycol 2010 Sep;48(6):800-6

Centraalbureau voor Schimmelcultures, CBS-KNAW Fungal Biodiversity Centre, Utrecht, The Netherlands.

A new species of Fonsecaea, Fonsecaea nubica, morphologically similar to F. pedrosoi and F. monophora, is described using multilocus molecular data including AFLP profiles, sequences of the ribosomal internal transcribed spacers (ITS), and partial sequences of the cell division cycle (cdc42), beta-tubulin (tub1) and actin (act1) genes. Read More

View Article
September 2010

Cerebral phaeohyphomycosis caused by Fonsecaea monophora.

Med Mycol 2005 Aug;43(5):465-72

Department of Neurosurgery, Leeds General Infirmary, Leeds, UK.

We report a case of cerebral phaeohyphomycosis in a 53-year-old immunocompetent diabetic male, caused by Fonsecaea monophora. Computerized tomography of the brain revealed an abscess, which yielded F. monophora in pure culture. Read More

View Article
August 2005

Chromoblastomycosis due to Fonsecaea monophora in a man with nephritic syndrome.

Mycopathologia 2015 Jun 10;179(5-6):447-52. Epub 2015 Jan 10.

Department of Dermatology, Southwest Hospital of the Third Military Medical University, Chongqing, 400038, China.

Chromoblastomycosis is a chronic subcutaneous mycosis caused by dematiaceous fungi. Fonsecaea monophora, a new species segregated from F. pedrosoi, may be the most prevalent pathogen of chromoblastomycosis in southern China. Read More

View Article
June 2015